Pyrazolylbenzothiazole derivatives and their use as therapeutic agents
Topical formulations and method of using the same are provided. The topical formulation comprises a pyrazolylbenzothiazole derivative of the following formula (1) wherein X, R 1 , R 2 , R 3 and R 4 are described herein.
1. A topical composition comprising a pharmaceutically acceptable excipient and 2-(3-Amino-5-methyl-1H-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic acid methylamide.
2. A method for relieving or causing regression of psoriasis or irritant contact dermatitis in a patient in need thereof, comprising topically applying a therapeutically effective amount of the topical composition of claim 1 .
3. A method for relieving or causing regression of of psoriasis in a patient comprising topically applying a therapeutically effective amount of the topical composition of claim 1 .
4. A method for relieving or causing regression of irritant contact dermatitis or allergic contact dermatitis in a patient comprising topically applying a therapeutically effective amount of the topical composition of claim 1 .