Artificial bone and joint compositions and methods of use and manufacture
The present invention provides a ceramic porous body for in-vitro and in-vivo use comprising a composition comprising a calcium aluminate (CA) containing phase and optionally at least one of an accelerator, a retarder, a surfactant, a foaming agent, a reactive alumina, water, a fiber, and a biologically active material, and combinations thereof. Ceramic compositions are provides as well as method of using the ceramic compositions and methods of manufacturing a ceramic porous body. The ceramic porous bodies of this invention may be used as artificial bones, joints, in-vitro support structures, and in-vivo support structures for cells, tissues, organs, and nerve growth and regeneration.
1. A porous ceramic composition consisting essentially of:
a calcium aluminate (CA) containing phase having the formula C n A y , wherein n is an integer from about 1 to about 12 and y is an integer from about 1 to about 24, said CA containing phase having at least a CaAl 2 O 4 phase and a CaAl 4 O 7 phase, including phosphate containing phases resulting from the interaction of C n A y , C n A y -hydrates wherein n is an integer from about 1 to about 12 and y is an integer from about 1 to about 24, CaO, Al n O y , and Al n O y -hydrates wherein n is an integer from about 1 to about 12 and y is an integer from about 1 to about 24 with P n O y x , wherein in the formula P n O y n is an integer 1, 2, or 3 and y is an integer 3, 4, or 7 and x is a negatively charged integer of 1, 3, or 4; and
a biologically active material that comprises one or more proteins for promoting bone growth.
2. The porous ceramic composition of claim 1 further including interconnected porosity.
3. The porous ceramic composition of claim 1 that supports stem cells.
4. The porous ceramic composition of claim 3 wherein said stem cells differentiate into osteoblasts.
5. The ceramic porous composition of claim 1 that is rehydrated in-vivo.
6. The porous ceramic composition of claim 1 further including wherein said phosphate is a raw material for osteoblast precipitation of natural bone.
7. The porous ceramic composition of claim 6 wherein said phosphate is calcium orthophosphate.