Torsionally flexible, sealed drive
A simple, robust and low-cost torsionally flexible, sealed drive that allows external drives to provide agitation within a container. A torsionally flexible tube is sealed to a torsionally rigid portion of a container. A second end of the tube is sealed to a driven element within the container. The driven element is coupled to a drive-shaft that is partly contained within the tube. Motion of the protruding end of the drive shaft imparts a corresponding motion to the driven element, while maintaining a water-tight seal between container and drive-shaft. One useful motion is a rotary oscillation. A stepper motor may operate via such a drive to impart a rotary oscillation to an impellor in a bioreactor, or mixing container, suitable for agitating a cell culture in a nutrient medium or hydrating a powdered media in water. The drive is suited to use in disposable bioreactors and mixers.
1. A torsionally flexible, sealed drive apparatus, comprising:
a torsionally flexible tube having a first end in fixed sealed cooperation with an aperture in a substantially torsionally rigid barrier element, and a second end in fixed sealed cooperation with a first end of a drive shaft, and wherein said drive shaft is partially disposed within said torsionally flexible tube and said second end of the flexible tube is rotatable relative to the first end of the flexible tube about a central axis such that said drive shaft is rotationally oscillatable about the central axis.
2. The apparatus of claim 1 further comprising a container and wherein said torsionally rigid barrier element surrounds an aperture in said container.
3. The apparatus of claim 2 , wherein said sealed cooperation of said second end of said torsionally flexible tube and said first end of said drive shaft further comprises a driven element contained in said container, and wherein said second end of said torsionally flexible tube is in sealed cooperation within said driven element, and wherein said first end of said drive shaft is adapted to couple with said driven element such that oscillation of said drive shaft about a central axis imparts a corresponding oscillation to said driven element.
4. The apparatus of claim 3 wherein said driven element is driveable in a rotary oscillatory motion comprising a clockwise motion of at least 10 degrees followed by an anticlockwise motion of at least 10 degrees.
5. The apparatus of claim 3 wherein said driven element is driveable in a rotary oscillatory motion comprising a clockwise motion of at least 270 degrees followed by an anticlockwise motion of at least 270 degrees.
6. The apparatus of claim 3 wherein said drive shaft is further adapted to releasably couple with said driven element.
7. The apparatus of claim 3 wherein said driven element is an impellor.
8. The apparatus of claim 3 wherein said container is a collapsible vessel.
9. The apparatus of claim 3 further comprising a stepper motor coupled to a second end of said drive shaft.
10. The apparatus of claim 2 , further comprising a driven element contained in said container, and wherein a second end of said drive shaft is adapted to couple with said driven element, such that oscillation of said drive shaft about a central axis imparts a corresponding oscillation to said driven element.
11. The apparatus of claim 10 wherein said driven element is driveable in a rotary oscillatory motion comprising a clockwise motion of at least 10 degrees followed by an anticlockwise motion of at least 10 degrees.
12. The apparatus of claim 10 wherein said driven element is driveable in a rotary oscillatory motion comprising a clockwise motion of at least 270 degrees followed by an anticlockwise motion of at least 270 degrees.
13. The apparatus of claim 10 wherein said driven element is an impellor.
14. The apparatus of claim 10 wherein said container is a collapsible vessel.
15. The apparatus of claim 10 further comprising a stepper motor coupled to a first end of said drive shaft.
16. The apparatus of claim 15 wherein said stepper motor is releasably coupled to said first end of said drive shaft.
17. A method of providing oscillating, rotary motion across a sealed barrier, comprising:
providing a torsionally flexible tube having a first end in fixed sealed cooperation with an aperture in a substantially torsionally rigid barrier element, and a second end in fixed sealed cooperation with a first end of a drive shaft, said second end of the flexible tube being rotatable relative to the first end of the flexible tube about a central axis, and wherein said drive shaft is partially disposed within said torsionally flexible tube; and
imparting an oscillating, rotary motion to said drive shaft about said central axis.
18. The method of claim 17 further comprising providing a container such that said torsionally barrier element surrounds an aperture in said container.
19. The method of claim 17 , further comprising providing a driven element contained in said container, in sealed cooperation of said second end of said torsionally flexible tube and adapted to couple with said drive shaft, thereby providing said sealed cooperation between said second end of said torsionally flexible tube and said drive shaft.
20. The method of claim 17 further comprising providing a driven element contained in said container, and adapted to couple with a second end of said drive shaft.
21. A mixer assembly comprising:
a container defining an aperture thereinto; and
a torsionally flexible, sealed drive apparatus including a torsionally flexible tube having a first end in fixed sealed cooperation with the aperture of the container, and a second end in fixed sealed cooperation with a first end of a drive shaft,
wherein said drive shaft is partially disposed within said torsionally flexible tube and said second end of the flexible tube is rotatable relative to the first end of the flexible tube about a central axis such that said drive shaft is rotationally oscillatable about the central axis.