Macrolide compounds and methods and intermediates useful for their preparation
The present invention provides intermediate compounds and synthetic methods that can be used to prepare complex cyclic compounds including macrolides. The invention also provides cyclic compounds that have useful biological properties such as antiinfective, antiinflammatory, or antitumor properties.
1. A compound of formula 239a:
wherein:
R 239a is H or a hydroxy protecting group;
R 239b is H or a hydroxy protecting group; and
R x is H, halo, amino, or cyano.
2. A compound of formula 239a:
wherein:
R 239b is H or benzyl;
R 239b is H or benzyl; and
R x is fluoro, chloro, or bromo.
3. A compound of formula 239:
4. A compound of formula 239a:
wherein:
R 239a is H or a hydroxy protecting group;
R 239b is H or a hydroxy protecting group; and
R x is H.