Method for the preparation of a crystalline form
The invention relates to a method for the preparation for a crystalline form of 1-chloro-4-(β-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene. In addition the invention relates to a crystalline form obtainable by this method, to a pharmaceutical composition and to the use thereof for preparing medicaments.
1. A method for preparing a crystalline form of a compound 1-chloro-4-(B-D-glucopyranos-1-yl)-2-[4-((S)-tetrahydrofuran-3-yloxy)-benzyl]-benzene comprising the following steps:
(a) dissolving the compound in a mixture of at least two solvents to form a solution wherein the first solvent is selected from the group of solvents consisting of toluene and tetrahydrofuran, and the second solvent is selected from the group of solvents consisting of methanol, ethanol, 1-propanol and 2-propanol;
(b) storing the solution to precipitate the crystalline form of the compound out of solution;
(c) isolating the crystalline form of the compound from the solution.
2. A method according to the claim 1 , wherein the first solvent is toluene.
3. A method according to the claim 2 , wherein the second solvent is ethanol, 1-propanol or 2-propanol.
4. A method according to the claim 1 , wherein the mixture of at least two solvents is selected from the group of combinations consisting of toluene/ethanol, toluene/1-propanol and toluene/2-propanol.
5. A method according to the claim 1 , wherein the crystalline form is characterized by an X-ray powder diffraction pattern that comprises peaks at 18.84, 20.36 and 25.21 degrees 2Θ (±0.1 degrees 2Θ), wherein said X-ray powder diffraction pattern is made using CuK α1 radiation.
6. A method according to the claim 4 , wherein the mixture of at least two solvents is the combination consisting of toluene/ethanol.
7. A method according to the claim 4 , wherein the weight ratio of the first solvent to the second solvent is in the range from about 1:5 to 5:1.
8. A method according to the claim 4 , wherein the weight ratio of the first solvent to the second solvent is in the range from about 1:2 to 2:1.
9. A method according to the claim 1 , wherein the mixture of at least two solvents is selected from the group of combinations consisting of tetrahydrofuran/ethanol, tetrahydrofuran/l-propanol and tetrahydrofuran/2-propanol.
10. A method according to the claim 9 , wherein the weight ratio of the first solvent to the second solvent is in the range from about 1:10 to 2:1.
11. A method according to the claim 9 , wherein the weight ratio of the first solvent to the second solvent is in the range from about 1:5 to 1:1.
12. A method according to the claim 9 , wherein the weight ratio of the first solvent to the second solvent is in the range from about 1:4 to 1:2.
13. A method according to claim 5 , wherein the X-ray powder diffraction pattern further comprises peaks at 14.69, 19.16 and 19.50 degrees 2Θ (±0.1 degrees 2Θ), wherein said X-ray powder diffraction pattern is made using CuK α1 radiation.