Analyzer apparatus and methods for lung disease

1. An apparatus arranged to give an output indicative of the initiation of a chronic obstructive pulmonary disorder (COPD)-related disease response, the apparatus comprising:

a patient information input unit arranged to receive patient information input thereto, the patient information comprising a plurality of scores relating to clinical indicators of lung disease state;

a biomarker detection unit arranged to receive a sample from a patient, to detect a biomarker in the sample and to generate biomarker information in response to a detected biomarker, wherein the biomarker information comprises one or more scores determined with reference to a severity scale, wherein the biomarker detection unit comprises a lab on chip unit, and wherein biomarker detection unit is arranged to receive a sample comprising: sputum, breath, and saliva;

a memory unit to store the biomarker information and the patient information;

a processing unit arranged to operate on the biomarker information and the patient information in the memory unit to determine a lung disease state for the patient; and

an output unit arranged to provide an output indicative of lung disease state according to the determination made by the processing unit;

wherein the patient information includes a plurality of patient self-reported scores determined with reference to a severity scale, the scores relating to the patient's perceived own symptoms and/or lung function and comprising: an amount of coughing score; an amount of sputum produced score; a texture of sputum produced score; and a color of sputum produced score; and

wherein the biomarker information comprises a plurality of scores determined from the sample with reference to a severity scale and relating to the presence of, or a change in the expression level of one or more of: C-reactive protein, neutrophil elastase, Il-8, myeloperoxidase, and procalcitonin; and

wherein the severity scale of the patient self-reported scores and the severity scale of the biomarker scores each utilize a same set of discrete numbers.

2. The apparatus of claim 1 , wherein the biomarker detection unit is arranged to also receive a sample comprising blood and/or serum.

3. The apparatus of claim 1 , wherein the memory unit is arranged such that patient information stored therein is associated with timing data relating to the time at which: the patient information is received; or the patient information is stored.

4. The apparatus of claim 1 , wherein the memory unit is arranged to store a plurality of determined disease states, and timing data relating to the time at which each determination was made.

5. The apparatus of claim 1 , wherein the memory unit is arranged to store a plurality of pieces of biomarker information relating to a corresponding plurality of samples received over time from a patient.

6. The apparatus of claim 1 , wherein the memory unit is arranged to store a plurality of pieces of patient information received over time from a patient.

7. The apparatus of claim 1 , wherein the memory unit is arranged such that biomarker information stored therein is associated with timing data relating to the time at which: the sample is received; the biomarker information is generated; or the biomarker information is stored.

8. The apparatus of claim 1 , wherein the memory unit is arranged to store a sequence of biomarker information and/or patient information recorded over time.

9. The apparatus of claim 1 , wherein the processing unit is arranged to operate on more than one piece of biomarker information stored in the memory unit.

10. The apparatus of claim 1 , wherein the processing unit is arranged to operate on more than one piece of patient information stored in the memory unit.

11. The apparatus of claim 1 , wherein the processing unit is arranged to operate on a sequence of biomarker information and/or patient information recorded over time.

12. The apparatus of claim 1 , wherein the processor unit is arranged to operate on more than one previously determined disease state stored in the memory unit.

13. The apparatus of claim 1 , wherein the output unit is arranged to provide an output indicative of lung disease state according to the determination made by the processing unit, the output indicating the state as either stable or changing.

14. The apparatus of claim 1 , wherein the output unit is arranged to provide an output indicative of the initiation of a COPD-related disease response.

15. The apparatus of claim 1 , wherein the output unit is arranged to produce a local output to a local user, and/or is arranged to transmit information from the apparatus to a remote monitoring station.

16. The apparatus of claim 1 , wherein the units are provided in a single integrated apparatus.

17. A method of identifying an individual having chronic obstructive pulmonary disorder (COPD) that is responsive to a treatment, the method comprising steps of: determining a COPD disease state for the individual; providing a treatment appropriate to the COPD disease state; monitoring the COPD disease state according to the apparatus of claim 1 ; and identifying the individual as responsive to the treatment according to changes in the monitored disease state.

18. A method of assaying the efficacy of a treatment for chronic obstructive pulmonary disorder (COPD) in an individual, said method comprising steps of: identifying an individual having COPD; determining a COPD state for the individual; providing a treatment; monitoring the COPD state according to the apparatus of claim 1 ; and identifying the treatment as effective according to changes in the monitored disease state.

19. A method of generating an output indicative of initiation of a chronic obstructive pulmonary disorder (COPD)-related disease response, the method comprising:

receiving, via a patient information input unit, patient information comprising a plurality of scores relating to clinical indicators of lung disease state;

receiving, via a biomarker detection unit having a lab on chip unit, a patient sample comprising: sputum, breath, and saliva;

detecting a biomarker in the sample and generating biomarker information in response to the detected biomarker, wherein the biomarker information comprises one or more scores determined with reference to a severity scale;

storing the biomarker information and the patient information in a memory unit;

operating on the biomarker information and the patient information in the memory unit to determine a lung disease state for the patient; and

providing an output indicative of the so-determined lung disease state;

wherein the patient information a plurality of patient self-reported scores determined with reference to a severity scale, the scores relating to the patient's perceived own symptoms and/or lung function and comprising: an amount of coughing score; an amount of sputum produced score; a texture of sputum produced score; and a color of sputum produced score;

wherein the biomarker information comprises a plurality of scores determined from the sample with reference to a severity scale and relating to the presence of, or a change in expression level of one or more of: C-reactive protein, neutrophil elastase; IL-8; myeloperoxidase; and procalcitonin; and

wherein the severity scale of the patient self-reported scores and the severity scale of the biomarker scores each utilize a same set of discrete numbers.

20. A method of identifying an individual having chronic obstructive pulmonary disorder (COPD) that is responsive to a treatment, the method comprising steps of: determining a COPD state for the individual; providing a treatment appropriate to the COPD state; monitoring the lung disease state according to the method of claim 19 ; and identifying the individual as responsive to the treatment according to changes in the monitored disease state.

21. A method of assaying the efficacy of a treatment for chronic obstructive pulmonary disorder (COPD) in an individual, said method comprising steps of: identifying an individual having COPD; determining a lung disease state for the individual; providing a treatment; monitoring the COPD state according to the method of claim 19 ; and identifying the treatment as effective according to changes in the monitored disease state.