Siderophore conjugate immunogenic compositions and vaccines
View Patent ↗An immunogenic composition comprising a siderophore covalently linked to a pharmaceutically acceptable carrier molecule wherein the antigenicity of the siderophore moiety is sufficient to stimulate an immunologic response to the siderophore when the composition is circulating in the bloodstream of a human or non-human animal and vaccine.
1. An immunogenic composition comprising a conjugate, wherein the conjugate comprises a siderophore covalently linked to a pharmaceutically acceptable carrier molecule, wherein:
the siderophore is vibriobactin;
the pharmaceutically acceptable carrier molecule comprises a protein; and
the antigenicity of the conjugate is sufficient to stimulate an immunologic response to said conjugate when said conjugate is circulating in the bloodstream of a human or non-human animal.
2. The immunogenic composition of claim 1 , wherein said protein comprises a vibriobactin receptor protein.
3. The immunogenic composition of claim 1 , wherein said protein comprises bovine serum albumin (BSA) or ovalbumin (OVA).
4. The immunogenic composition of claim 1 , wherein the immunogenic composition is suitable for administration to a human or non-human animal and further comprises a pharmaceutically acceptable carrier.
5. The immunogenic composition of claim 2 , wherein the siderophore receptor protein is a siderophore receptor protein of at least one strain of bacteria.
6. The immunogenic composition of claim 5 , wherein the bacteria are Vibrio cholerae.
7. A method for synthesizing the immunogenic composition of claim 1 comprising covalently linking the siderophore to the pharmaceutically acceptable carrier molecule.