Pharmaceutical composition comprising cyclobenzaprine and aceclofenac in association
View Patent ↗The present invention relates to an association of active ingredients. More specifically: to an association of cyclobenzaprine and aceclofenac. Additionally, the present invention is also related to the use of aceclofenac and cyclobenzaprine, in association for the preparation of a medicine useful in the treatment of painful muscular diseases, as well as to a method of treatment of painful muscular diseases using an association of aceclofenac and cyclobenzaprine.
1. A pharmaceutical composition comprising:
(a) cyclobenzaprine or its salts;
(b) aceclofenac or its salts; and
(c) optionally one or more pharmaceutically acceptable excipients;
wherein said pharmaceutical composition comprises cyclobenzaprine and aceclofenac in a single dosage unit in the form of tablet or hard capsule; and wherein said cyclobenzaprine is not in contact with said aceclofenac.
2. The pharmaceutical composition of claim 1 , wherein said tablet is a multilayer tablet in which the layer comprising cyclobenzaprine is physically separated from the layer comprising aceclofenac by an isolating intermediate layer.
3. The pharmaceutical composition of claim 1 , wherein said capsule comprises:
(a) cyclobenzaprine in the form of granules or tablets; and
(b) aceclofenac in the form of granules or tablets;
wherein said cyclobenzaprine or aceclofenac granules or tablets are coated.