IP Library Granted Patent US 8,840,873
Granted Patent B2
US 8,840,873 · App. 11/388,930 · Granted Sep 23, 2014

Method of treating second and third degree burns using oxidative reductive potential water solution

Inventor: Hojabr Alimi (Santa Rosa, CA)
Assignee: Oculus Innovative Sciences, Inc.
A61K33/20A61N1/44A61L2/0088
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Quick Facts
Patent No.
US 8,840,873
App. No.
11/388,930
Granted
Sep 23, 2014
Kind
B2
Abstract

A method of treating burns, preferably second and third degree burns, by administration of an oxidative reduction potential (ORP) water solution that is stable for at least twenty-four hours is provided.

Claims (52)

1. A method of treating a second or third degree burn in a patient, comprising: administering an oxidative reductive potential water solution to the patient in an amount sufficient to treat the burn,

wherein the solution has a pH of 7.4 to 7.6,

wherein the solution is stable for at least two months,

wherein the solution comprises anode water and cathode water,

wherein the oxidative reductive potential water solution comprises free chlorine species at a level of from 50 ppm to 80 ppm,

wherein the free chlorine species is selected from the group selected from the group consisting of hypochlorous acid, hypochlorite ions, sodium hypochlorite, chlorite ions, chloride ions, dissolved chlorine gas, and mixtures thereof, and

wherein the free chlorine species comprises at least one of: hypochlorous acid in an amount of 15 ppm to 35 ppm and sodium hypochlorite in an amount of 25 ppm to 50 ppm.

2. The method of claim 1 , wherein the cathode water is present in an amount of from 10% by volume to 50% by volume of the solution.

3. The method of claim 2 , wherein the cathode water is present in an amount of from 20% by volume to 40% by volume of the solution.

4. The method of claim 2 , wherein the anode water is present in an amount of from 50% by volume to 90% by volume of the solution.

5. The method of claim 1 , wherein the solution is administered to the patient by spraying the burn with the solution.

6. The method of claim 5 , wherein the solution is administered to the patient by spraying the burn with the solution with a high pressure irrigation device.

7. The method of claim 5 , wherein the burn is moistened with the solution for at least five minutes.

8. The method of claim 7 , wherein the burn is moistened with the solution for at least 15 minutes.

9. The method of claim 1 , wherein the solution is administered to the patient at least daily.

10. The method of claim 9 , wherein the solution is administered to the patient three times a day.

11. A method of treating a second or third degree burn in a patient, comprising:

administering an oxidative reductive potential water solution to the patient in an amount sufficient to treat the burn,

wherein the oxidative reductive potential water solution comprises free chlorine species at a level of from 50 ppm to 80 ppm,

wherein the free chlorine species in the solution comprises hypochlorous acid in an amount from 15 ppm to 35 ppm and sodium hypochlorite in an amount from 25 ppm to 50 ppm,

wherein the solution is stable for at least two months, and

wherein the pH of the solution is from 7.4 to 7.6.

12. The method of claim 11 , wherein the solution is administered to the patient by spraying the burn with the solution.

13. The method of claim 12 , wherein the solution is administered to the patient by spraying the burn with the solution with a high pressure irrigation device.

14. The method of claim 12 , wherein the burn is moistened with the solution for at least five minutes.

15. The method of claim 14 , wherein the burn is moistened with the solution for at least 15 minutes.

16. The method of claim 11 , wherein the solution is administered to the patient at least daily.

17. The method of claim 16 , wherein the solution is administered to the patient three times a day.

18. A method of treating a second or third degree burn in a patient, comprising:

(1) spraying the burn with an oxidative reductive potential water solution at high pressure;

(2) optionally soaking the burn with an oxidative reductive potential water solution;

(3) spraying the burn with an oxidative reductive potential water solution;

(4) allowing the oxidative reductive potential water solution to moisten the burn, wherein the oxidative reductive potential water solution has a pH of 7.4 to 7.6 and is stable for at least two months,

wherein the oxidative reductive potential water solution comprises free chlorine species at a level of from 50 ppm to 80 ppm,

wherein the free chlorine species is selected from the group selected from the group consisting of hypochlorous acid, hypochlorite ions, sodium hypochlorite, chlorite ions, chloride ions, dissolved chlorine gas, and mixtures thereof; and

wherein the free chlorine species comprises at least one of: hypochlorous acid in an amount of 15 ppm to 35 ppm and sodium hypochlorite in an amount of 25 ppm to 50 ppm.

19. The method of claim 18 , wherein the burn is subject to debridement therapy prior to spraying.

20. The method of claim 1 , wherein antibiotics are not administered to the patient during treatment of the burn.

21. The method of claim 11 , wherein antibiotics are not administered to the patient during treatment of the burn.

22. The method of claim 18 , wherein antibiotics are not administered to the patient during treatment of the burn.

23. The method of claim 18 , further comprising:

applying skin grafts to the patient.

24. The method of claim 18 , wherein steps (3)-(4) are repeated three times a day.

25. The method of claim 18 , wherein steps (1)-(4) are repeated until the burn is sufficiently healed.

26. The method of claim 18 , further comprising:

administering antibiotics to the patient.

27. The method of claim 1 , wherein an extent of burn coverage in the patient that is treated is in a range of from above 0% to 19%.

28. The method of claim 11 , wherein an extent of burn coverage in the patient that is treated is in a range of from above 0% to 19%.

29. The method of claim 18 , wherein an extent of burn coverage in the patient that is treated is in a range of from above 0% to 19%.

30. The method of claim 5 , wherein an extent of burn coverage in the patient that is treated is in a range of from 30% to 49%.

31. The method of claim 11 , wherein an extent of burn coverage in the patient that is treated is in a range of from 30% to 49%.

32. The method of claim 18 , wherein an extent of burn coverage in the patient that is treated is in a range of from 30% to 49%.

Assignments (6)
CHANGE OF NAME Recorded Jan 5, 2017
From: OCULUS INNOVATIVE SCIENCES, INC.
To: SONOMA PHARMACEUTICALS, INC.
Reel/Frame 041257/0375 →
RELEASE OF LIEN Recorded Feb 24, 2015
From: VENTURE LENDING & LEASING V, INC.
To: OCULUS INNOVATIVE SCIENCES, INC.
Reel/Frame 035090/0111 →
RELEASE OF LIEN Recorded Feb 24, 2015
From: VENTURE LENDING & LEASING VI, INC.
To: OCULUS INNOVATIVE SCIENCES, INC.
Reel/Frame 035090/0143 →
SECURITY INTEREST Recorded Jul 7, 2011
From: OCULUS INNOVATIVE SCIENCES, INC.
To: VENTURE LENDING & LEASING V, INC.
Reel/Frame 026619/0196 →
SECURITY AGREEMENT Recorded Jul 7, 2011
From: OCULUS INNOVATIVE SCIENCES, INC.
To: VENTURE LENDING & LEASING VI, INC.
Reel/Frame 026619/0235 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 7, 2006
From: ALIMI, HOJABR
To: OCULUS INNOVATIVE SCIENCES, INC.
Reel/Frame 017736/0334 →
Continuity (9)
Provisional Application 60760635 · Jan 20, 2006
Provisional Application 60760567 · Jan 20, 2006
Provisional Application 60760645 · Jan 20, 2006
Provisional Application 60760557 · Jan 20, 2006
Provisional Application 60730743 · Oct 27, 2005
Provisional Application 60667101 · Mar 31, 2005
Provisional Application 60664361 · Mar 23, 2005
Provisional Application 60676883 · May 2, 2005
Related Publication 20060241546A1 · Oct 26, 2006