Pyrrolidone derivatives for use as MetAP-2 inhibitors

1. A compound that is

Com-

pound

No.

Name and/or structure

“A1”

6-[(R)-2-(Naphthalen-1-yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A2”

4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-

ylmethoxy]naphthalene-1-carbaldehyde

“A3”

6-[(R)-2-(4-Morpholin-4-ylmethylnaphthalen-1-yloxymethyl)-

pyrrolidin-1-yl]-9H-purine

“A4”

6-[(R)-2-(4-Butoxymethylnaphthalen-1-

yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A6”

Morpholin-4-yl(4-{2-[1-(9H-purin-6-yl)pyrrolidin-2-yl]-

ethyl}naphthalen-1-yl)methanone

“A8”

6-[(R)-4,4-Difluoro-2-(naphthalen-1-

yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A14”

N-Cyclopropyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A15”

2-[1-(1H-Imidazol-4-yl)meth-(Z)-ylidene]-5-[(R)-1-(9H-purin-6-

yl)pyrrolidin-2-ylmethoxy]-3,4-dihydro-2H-naphthalen-1-one

“A15.1”

2-(1H-Imidazol-4-ylmethyl)-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]-3,4-dihydro-2H-naphthalen-1-one

“A18”

8-Bromo-6-[(R)-2-(naphthalen-1-yloxymethyl)pyrrolidin-

1-yl]-9H-purine

“A19”

“A20”

“A23”

4-[(R)-2-(Naphthalen-1-yloxymethyl)pyrrolidin-

1-yl]pyrido[2,3-d]pyrimidine

“A25”

6-[(R)-2-(Naphthalen-1-yloxymethyl)pyrrolidin-

1-yl]purin-9-yl-amine

“A26”

6-[(2R,4R)-4-Fluoro-2-(naphthalen-1-

yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A28”

6-[(2R,4S)-4-Fluoro-2-(naphthalen-1-

yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A30”

(3R,5R)-5-(Naphthalen-1-yloxymethyl)-1-

(9H-purin-6-yl)-pyrrolidin-3-ol

“A31”

6-(R)-2,2-Difluoro-5-(naphthalen-1-yloxymethyl)pyrrolidin-

1-yl]-9H-purine

“A33”

N-[6-(3-{2-[1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-5-

trifluoromethylphenyl}ureidomethyl)-

1H-benzimidazol-2-yl]-acetamide

“A34”

N-Methyl-4-[4-(3-{2-[1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]-5-trifluoromethyl-

phenyl}ureidomethyl)phenoxy]pyridine-2-carboxamide

“A35”

N-Methyl-4-[4-(3-{2-[1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]-5-trifluoro-

methylphenyl}ureido)phenoxy]pyridine-2-carboxamide

“A36”

N-Methyl-4-[3-(3-{2-[1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]-5-trifluoromethyl-

phenyl}ureido)phenoxy]pyridine-2-carboxamide

“A37”

6-[(R)-2-(Dibenzofuran-3-yloxymethyl)pyrrolidin-1-

yl]-9H-purine

“A38”

4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-9H-carbazole

“A39”

Ethyl 1-butyl-2-methyl-5-[(R)-1-(2H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-1H-indole-3-carboxylate

“A40”

6-[(R)-2-(1H-Indol-4-yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A41”

1-{7-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-

ylmethoxy]benzofuran-2-yl}ethanone

“A42”

5-Piperidin-1-ylmethyl-8-[(R)-1-(9H-purin-6-yl)pyrroidin-2-yl-

methoxy]quinoline

“A43”

8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]quinoline

“A44”

5-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]isoquinoline

“A45”

7-Benzyloxy-6-methoxy-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinazoline

“A46”

4-(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]quinazoline

“A47”

2-{2-[2-({4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-1-ylmethyl}amino)ethoxy]ethoxy}ethyl-

amine

“A48”

N-Methyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A49”

2-Methyl-8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

yl-methoxy]quinoline

“A50”

N-Ethyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A51”

5-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-

ylmethoxy]-3,4-dihydro-2H-naphthalen-1-one

“A52”

2-Hydroxymethylene-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-3,4-dihydro-2H-naphthalen-1-one

“A53”

[1-Oxo-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-3,4-

dihydro-1H-naphthalen-(2Z)-ylidene]acetic acid

“A54”

8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-3,4-dihydro-

1H-naphthalen-2-one

“A55”

6-[(R)-2-(5,6,7,8-Tetrahydronaphthalen-1-yloxymethyl)-

pyrrolidin-1-yl]-9H-purine

“A56”

4-Morpholin-4-ylmethyl-8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline

“A57”

1-Chloro-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]isoquinoline

“A58”

6-{(R)-2-[5-(2-Methoxyethoxy)naphthalen-1-yloxymethyl]-

pyrrolidin-1-yl}-9H-purine

“A59”

2-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethyl]-

2H-isoquinolin-1-one

“A60”

(2-Morpholin-4-ylethyl)-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-1-ylmethyl]amine

“A61”

6-[(R)-2-(2-Piperidin-1-ylmethylnaphthalen-1-yloxymethyl)-

pyrrolidin-1-yl]-9H-purine

“A62”

6-[(R)-2-(Biphenyl-2-yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A63”

6-[(R)-2-(Biphenyl-3-yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A64”

6-[(R)-2-(Biphenyl-4-yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A65”

Methyl 3-{5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]pyrimidin-2-yl}benzoate

“A66”

N-(2-Morpholin-4-ylethyl)-3-{5-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]pyrimidin-2-yl}benzamide

“A67”

N-Methyl-2-[1-oxo-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-3,4-dihydro-1H-naphthalen-(2Z)-ylidene]acetamide

“A68”

N-(2-Hydroxypropyl)-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A69”

N-Cyclopentyl-4-[(R)-1-(9H-purin-6-yl)pyrroidin-2-yl-

methoxy]quinoline-2-carboxamide

“A70”

N-Butyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A71”

N-Propyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A72”

6-[(R)-2-(2,2-Dimethyl-2,3-dihydrobenzofuran-7-yloxymethyl)-

pyrrolidin-1-yl]-9H-purine

“A73”

6-[(R)-2-(Benzoxazol-4-yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A75”

2,2,2-Trifluoro-1-{2-methyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]indol-1-yl{ethanone

“A77”

6-{(R)-2-[2-(4-Fluorophenyl)pyrimidin-5-yloxymethyl]-

pyrrolidin-1-yl}-9H-purine

“A80”

N-Cyclobutyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A81”

N-Pentyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A82”

2-[1-(4-Chloro-2-methyl-2H-pyrazol-3-yl)meth-(Z)-ylidene]-5-

[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]-3,4-dihydro-2H-naphthalen-1-one

“A83”

5-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-2-[1-(1H-

pyrazol-3-yl)meth-(Z)-ylidene]-3,4-dihydro-2H-naphthalen-1-one

“A84”

N-(2-Hydroxyethyl)-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A85”

N-(3-Hydroxypropyl)-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxamide

“A86”

5-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]quinoline

“A87”

8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]isoquinoline

“A88”

N-(3-Hydroxycyclobutylmethyl)-4-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]quinoline-2-carboxamide

“A89”

3-Methyl-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]isoquinoline

“A92”

N-(2-Morpholin-4-ylethyl)-N-{4-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]naphthalen-1-ylmethyl}acetamide

“A93”

4-[(R)-1-(9H-Purin-6-yl)pyrroidin-2-ylmethoxy]quinoline

“A94”

N-(2-Morpholin-4-ylethyl)-N-{4-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]naphthalen-1-ylmethyl}formamide

“A95”

(3-Morpholin-4-ylpropyl)-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]naphthalen-1-ylmethyl}amine

“A96”

(R)-2-(1H-Imidazol-4-ylmethyl)-5-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]-3,4-dihydro-2H-naphthalen-1-one

“A97”

(S)-2-(1H-Imidazol-4-ylmethyl)-5-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]-3,4-dihydro-2H-naphthalen-1-one

“A98”

N-(2-Piperidin-1-ylethyl)-N-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]naphthalen-1-ylmethyl}acetamide

“A99”

N-(1-Methyl-1H-pyrazol-3-ylmethyl)-N-{4-[(R)-1-(9H-purin-6-

yl)pyrrolidin-2-ylmethoxy]naplathalen-1-ylmethyl}acetamide

“A100”

N-(2,3-Dihydroxypropyl)-N-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]naphthalen-1-ylmethyl}acetamide

“A101”

N-(2-Piperidin-1-ylethyl)-N-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]naphthalen-1-ylmethyl}formamide

“A102”

N-(1-Methyl-1H-pyrazol-3-ylmethyl)-N-{4-[(R)-1-(9H-purin-6-

yl)pyrrolidin-2-ylmethoxy]naphthalen-1-ylmethyl}formamide

“A103”

6-[(R)-2-(2-Benzothiazol-2-ylphenoxymethyl)pyrrolidin-1-yl]-

9H-purine

“A104”

6-[(R)-2-(Imidazo[1,2-a]pyridin-8-

yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A105”

6-Chloro-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-2-

trifluoromethylquinoline

“A106”

6-{(R)-2-[7-(4-Benzylpiperazin-1-yl)naphthalen-1-yloxymethyl]-

pyrrolidin-1-yl}-9H-purine

“A107”

6-Dimethylamino-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalene-2-sulfonic acid

“A108”

Naphthalen-1-yl[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethyl]-amine

“A109”

1-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]isoquinoline

“A110”

6-{(R)-2-[4-(4-Propylpiperazin-1-ylmethyl)naphthalen-1-yl-

oxymethyl]pyrrolidin-1-yl}-9H-purine

“A111”

1-(4-{4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-1-ylmethyl}piperazin-1-yl)ethanone

“A112”

6-{(R)-2-[4-(4-Cyclopentylpiperazin-1-ylmethyl)naphthalen-1-

yloxymethyl]pyrrolidin-1-yl}-9H-purine

“A113”

6-((R)-2-{4-[4-(2-Methoxyethyl)piperazin-1-ylmethyl]-

naphthalen-1-yloxymethyl}pyrrolidin-1-yl)-9H-purine

“A114”

((R)-1-{4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-1-ylmethyl}pyrrolidin-2-yl)methanol

“A115”

6-[(R)-2-(7-Piperazin-1-ylnaphthalen-1-

yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A116”

1-(4-{8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl}piperazin-1-yl)ethanone

“A117”

6-Methyl-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-2-

trifluoromethylquinoline

“A118”

6-[(R)-2-(7-Methoxynaphthalen-1-

yloxymethyl)pyrrolidin-1-yl]-9H-purine

“A119”

6-[(R)-2-(7-Butoxy-5,6-dihydronaphthalen-1-yloxymethyl)-

pyrrolidin-1-yl]-9H-purine

“A120”

Benzyl 8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-3,4-

dihydro-1H-isoquinoline-2-carboxylate

“A121”

8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-3,4-dihydro-

1H-naphthalen-2-one

“A122”

8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-1,2,3,4-

tetrahydroisoquinoline

“A123”

4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-6-

trifluoromethylquinoline

“A124”

8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]naphthalen-2-ol

“A125”

(S)-2-(4-Chloro-2-methyl-2H-pyrazol-3-ylmethyl)-5-[(R)-1-(9H-

purin-6-yl)pyrrolidin-2-ylmethoxy]-

3,4-dihydro-2H-naplathalen-1-one

“A126”

(R)-2-(4-Chloro-2-methyl-2H-pyrazol-3-ylmethyl)-5-[(R)-1-(9H-

purin-6-yl)pyrrolidin-2-ylmethoxy]-

3,4-dihydro-2H-naphthalen-1-one

“A127”

N,N-Diethyl-3-hydroxy-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalene-2-carboxamide

“A128”

3-(4-{4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-1-ylmethyl}piperazin-1-yl)propionitrile

“A129”

(R)-5-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-2-(1H-

pyrazol-3-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

“A130”

(S)-5-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-2-(1H-

pyrazol-3-ylmethyl)-3,4-dihydro-2H-naphthalen-1-one

“A131”

8-{[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-

ylmethyl]-amino}naphthalen-2-ol

“A132”

8-{[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethyl]-

amino}naphthalene-2-sulfonic acid

“A133”

tert-Butyl (6-oxo-6-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-3,4-dihydro-1H-isoquinolin-2-yl}hexyl)carbamate

“A134”

3-(2-{6-[(R)-2-(7-Hydroxynaphthalen-1-yloxymethyl)pyrrolidin-

1-yl]purin-9-yl}ethyl)dihydrofuran-2-one

“A135”

3-{6-[(R)-2-(7-Hydroxynaphthalen-1-yloxymethyl)pyrrolidin-1-

yl]purin-9-yl}propionamide

“A136”

Ethyl 5-{6-[(R)-2-(7-hydroxynaphthalen-1-yloxymethyl)-

pyrrolidin-1-yl]purin-9-yl}pentanoate

“A137”

4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-6-

trifluoromethoxyquinoline

“A138”

6-Amino-1-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-

3,4-dihydro-1H-isoquinolin-2-yl}hexan-1-one

“A139”

Butyl 6-fluoro-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxylate

“A140”

6-Fluoro-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethoxy-2-

trifluoromethylquinoline 1-oxide

“A141”

6-Fluoro-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]quinoline-2-carboxylic acid

“A142”

6-[(R)-2-(7-Nitronaphthalen-1-yloxymethyl)pyrrolidin-

1-yl]-9H-purine

“A143”

(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethyl 2-methylamino-benzoate

“A144”

8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-

ylmethoxy]naphthalen-2-yl-amine

“A145”

6-{(R)-2-[7-(4-Methylpiperazin-1-yl)naphthalen-1-yloxymethyl]-

pyrrolidin-1-yl}-9H-purine

“A146”

6-[(R)-2-(7-Morpholin-4-ylnaphthalen-1-yloxymethyl)pyrrolidin-

1-yl]-9H-purine

“A147”

4-[(R)-1-(8-Fluoro-9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-1-ol

“A148”

4-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]isoquinoline

“A149”

N-(2-Morpholin-4-ylethyl)-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]quinoline-2-carboxamide

“A150”

N-(3-Morpholin-4-ylpropyl)-4-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]quinoline-2-carboxamide

“A151”

Methyl 5-fluoro-1-methyl-3-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]-1H-indole-2-carboxylate

“A152”

N,N-Dimethyl-3-[2-(4-methoxyphenyl)ethoxy]-8-[2-(4-methoxy-

phenyl)ethyl]-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalene-2-carboxamide

“A153”

6-{(R)-2-[1-(2,4-Dichlorophenyl)-1H-pyrazol-3-yloxymethyl]-

pyrrolidin-1-yl}-9H-purine

“A154”

1-Ethyl-3-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl}urea

“A155”

N-Ethyl-4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl}piperazine-1-carboxamide

“A156”

N-(Furan-2-ylmethyl)-4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]naphthalen-2-yl}piperazine-1-carboxamide

“A157”

Ethyl [(4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl}piperazine-1-carbonyl)amino]acetate

“A158”

[(4-{8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-yl-methoxy]naphthalen-

2-yl}piperazine-1-carbonyl)amino]acetic acid

“A159”

1-Furan-2-ylmethyl-3-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl}urea

“A160”

Methyl (S)-4-benzyloxycarbonylamino-4-{8-[(R)-1-(9H-purin-6-

yl)pyrrolidin-2-ylmethoxy]naphthalen-2-ylcarbamoyl}butyrate

“A161”

tert-Butyl ((S)-3-carbamoyl-1-{8-[(R)-1-(9H-purin-6-yl)-pyrrolidin-

2-ylmethoxy]naphthalen-2-ylcarbamoyl}propyl)-carbamate

“A162”

tert-Butyl ((R)-2-carbamoyl-1-{8-[(R)-1-(9H-purin-6-yl)-pyrrolidin-

2-ylmethoxy]naphthalen-2-ylcarbamoyl}ethyl)-carbamate

“A163”

tert-Butyl ((S)-2-(1H-imidazol-4-

yl)-1-(8-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]naphthalen-2-ylcarbamoyl}ethyl)-carbamate

“A164”

(S)-2-Amino-3-(1H-imidazol-4-yl)-N-{8-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]naphthalen-2-yl}propionamide

“A165”

N-(1-({8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl})-(S)-2-aminopentan-5-amide

“A166”

4-{8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]naphthalen-

2-yl}piperazine-1-carbaldehyde

“A167”

tert-Butyl [2-oxo-2-(4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl}piperazin-1-yl)ethyl]carbamate

“A168”

2-Amino-1-(4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl}piperazin-1-yl)ethanone

“A169”

1-{8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-1,2,3,4-

tetrahydronaphthalen-2-yl}pyrrolidin-3-ol

“A170”

1-{8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-1,2,3,4-

tetrahydronaphthalen-2-yl}azetidin-3-ol

“A171”

N-(1-{8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]-1,2,3,4-

tetrahydronaphthalen-2-yl}pyrrolidin-3-yl)acetamide

“A172”

(2-Morpholin-4-ylethyl)-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]isoquinolin-1-yl}amine

“A173”

N,N-Dimethyl-2-{1-oxo-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}acetamide

“A174”

N,N-Dimethyl-2-{(S)-1-oxo-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}acetamide

“A175”

N,N-Dimethyl-2-{(R)-1-oxo-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-

2-ylmethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}acetamide

“A176”

N-Ethyl-2-{1-oxo-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}acetamide

“A177”

(R)-2-Amino-N1-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yl}succinamide

“A178”

(3-Morpholin-4-ylpropyl)-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]isoquinolin-1-yl}amine

“A179”

N-Methyl-2-{1-oxo-5-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}acetamide

“A180”

N-(2-Hydroxyethyl)-2-{1-oxo-5-[(R)-1-(9H-purin-6-yl)-pyrrolidin-

2-ylmethoxy]-1,2,3,4-tetrahydronaphthalen-2-yl}acetamide

“A181”

N,N-Dimethyl-N′-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]isoquinolin-1-yl}ethane-1,2-diamine

“A182”

N,N-Dimethyl-N′-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]isoquinolin-1-yl}propane-1,3-diamine

“A183”

(S)-4-Carboxyamino-4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-ylcarbamoyl}butyric acid

“A184”

Ethyl 5-fluoro-1-methyl-3-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-1H-indole-2-carboxylate

“A185”

Ethyl 1-ethoxycarbonylmethyl-5-fluoro-3-[(R)-1-(9H-purin-6-

yl)pyrrolidin-2-ylmethoxy]-1H-indole-2-carboxylate

“A186”

3-(2-{8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-yl-

methoxy]naphthalen-2-yloxy}ethyl)dihydrofuran-2-one

“A187”

tert-Butyl ((S)-3-carbamoyl-1-{8-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]-3,4-dihydro-1H-isoquinoline-2-

carbonyl}propyl)carbamate

“A188”

tert-Butyl ((R)-1-carbamoylmethyl-2-oxo-2-{8-[(R)-1-(9H-purin-

6-yl)pyrrolidin-2-ylmethoxy]-3,4-dihydro-1H-isoquinolin-2-

yl}ethyl)carbamate

“A189”

tert-Butyl ((S)-1-(1H-imidazol-4-ylmethyl)-2-oxo-2-{8-[(R)-1-

(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-3,4-dihydro-1H-

isoquinolin-2-yl}ethyl)carbamate

“A190”

5-Fluoro-1-methyl-3-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-1H-indole-2-carboxylic acid

“A191”

(2-Morpholin-4-ylethyl)-{4-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-

ylmethoxy]quinolin-2-ylmethyl}amine

“A192”

(S)-5-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-3,4-

dihydro-1H-isoquinoline-2-carbonyl}pyrrolidin-2-one

“A193”

tert-Butyl ((S)-5-benzyloxycarbonylamino-6-oxo-6-{8-[(R)-1-

(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-3,4-dihydro-1H-

isoquinolin-2-yl}hexyl)carbamate

“A194”

(R)-3-Amino-4-oxo-4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-3,4-dihydro-1H-isoquinolin-2-yl}butyramide

“A195”

(S)-2-Amino-3-(1H-imidazol-4-yl)-1-{8-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]-3,4-dihydro-1H-isoquinolin-2-

yl}propan-1-one

“A196”

5-{8-[(R)-1-(9H-Purin-6-yl)pyrrolidin-2-ylmethoxy]naphthalen-

2-yloxy}pentanoic acid

“A197”

N-(4-Fluorobenzyl)-5-fluoro-1-methyl-3-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]-1H-indole-2-carboxamide

“A198”

2-(4-Fluorophenyl)ethyl 5-fluoro-1-methyl-3-[(R)-1-(9H-purin-6-

yl)pyrrolidin-2-ylmethoxy]-1H-indole-2-carboxylate

“A199”

Benzyl ((S)-5-amino-1-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-3,4-dihydro-1H-isoquinoline-2-carbonyl}pentyl)-carbamate

“A200”

N-[2-(4-Fluorophenyl)ethyl]-5-fluoro-1-{[2-(4-fluorophenyl]-

ethylcarbamoyl]methyl}-3-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-1H-indole-2-carboxamide

“A201”

(S)-3-Amino-4-oxo-4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-yl-

methoxy]-3,4-dihydro-1H-isoquinolin-2-yl}butyramide

“A202”

4-Oxo-4-{8-[(R)-1-(9H-purin-6-yl)pyrrolidin-2-ylmethoxy]-3,4-

dihydro-1H-isoquinolin-2-yl}butyramide

“A203”

[2-(4-Fluorophenyl)ethyl]-(2-{5-fluoro-3-[(R)-1-(9H-purin-6-yl)-

pyrrolidin-2-ylmethoxy]indol-1-yl}ethyl)amine

or a pharmaceutically usable salt, tautomer or stereoisomer thereof, or a mixture thereof.

2. A pharmaceutical compostion comprising at least one compound of the formula I according to claim 1 and/or pharmaceutically usable salt, tautomer stereoisomer thereof, and a pharmaceutically acceptable carrier.