IP Library › Granted Patent US 8,846,932
Granted Patent B2
US 8,846,932 · App. 13/801,380 · Granted Sep 30, 2014

Small molecules modulator of epigenetic regulation and their therapeutic applications

Inventors: Lin Chen (La Canada, CA); Nimanthi Jayathilaka (Los Angeles, CA); Aidong Han (Los Angeles, CA); Nicos A. Petasis (Hacienda Heights, CA)
Assignee: University of Southern California
C07C233/43C07D213/40A61K31/444C07K2299/00A61K31/00G01N33/6875G01N2500/00A61K31/167
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Quick Facts
Patent No.
US 8,846,932
App. No.
13/801,380
Granted
Sep 30, 2014
Kind
B2
Abstract

Disclosed are methods and compositions for modulating the function of transcription factors, especially transcription factors that recruit epigenetic regulators (histone modifying enzymes) to specific DNA promoters. The targeted transcription factors include but are not limited to the myocyte enhancing factor (MEF2), the forkhead/winged helix transcription factor FOXP3 and the transcription factor GATA3. Also disclosed are small molecule modulators of MEF2 and its associated factors that include but not limited to histone deacetylases (HDACs), p300/CBP and Cabin1 and the therapeutic applications thereof.

Claims (4)

1. A myocyte enhancer factor (MEF) inhibitor compound of formula (6)

2. A MEF inhibitor composition comprising a compound of formula (6)

3. A histone deacetylase (HDAC) inhibitor compound of formula (6)

4. A HDAC inhibitor composition comprising a compound of formula (6)

Assignments (1)
CONFIRMATORY LICENSE Recorded Mar 25, 2015
From: UNIVERSITY OF SOUTHERN CALIFORNIA
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 035280/0277 →
Continuity (4)
Division 12613521 · Nov 5, 2009
Provisional Application 61111689 · Nov 5, 2008
Provisional Application 61246934 · Sep 29, 2009
Related Publication 20130281703A1 · Oct 24, 2013