Microelectrode-equipped subdural therapeutic agent delivery strip

1. An apparatus for treating the brain, comprising:

a first fluid delivery device including a distal end sized and shaped for placement at a first target site between a dura mater and a pia mater of the brain, the first fluid delivery device including a first fluid lumen extending along a first fluid lumen path from a first fluid lumen proximal end to a first fluid lumen distal end open to a first outlet opening in the distal end of the first fluid delivery device to deliver fluids to a first target location and a second fluid lumen extending through the first fluid delivery device along a second fluid lumen path from a second fluid lumen proximal end to a second fluid lumen distal end open to the first outlet opening, wherein the first fluid lumen path is separated from the second fluid lumen path; and

a first microelectrode extending from a microelectrode proximal end to a first distal tip, the first microelectrode being mounted within the distal end of the first fluid delivery device for movement between an insertion position in which a first distal tip of the first microelectrode is received within the first fluid delivery device and a deployed position in which the first microelectrode extends out of the first fluid delivery device with the first distal tip thereof penetrating the pia mater to a first electrode target position in the cerebral cortex, wherein the first microelectrode is movable independently of the first fluid lumen.

2. The apparatus of claim 1 , further comprising:

a second microelectrode extending from the microelectrode proximal end to a second distal tip, the second microelectrode being mounted within the distal end of the first fluid delivery device movable between an insertion configuration in which the second distal tip thereof is received within the first fluid delivery device and a deployed configuration in which the second distal tip of the second microelectrode penetrates the pia mater to a second electrode target position in the cerebral cortex; and

a third fluid lumen extending through the first fluid delivery device from the first fluid lumen proximal end to a second outlet opening which, when the first fluid delivery device is at the first target site, opens to a second target location.

3. The apparatus of claim 2 , further comprising a fourth fluid lumen extending through the first fluid delivery device from the second fluid lumen proximal end to the second outlet opening.

4. The apparatus of claim 3 , further comprising:

a third microelectrode extending from the microelectrode proximal end to a third distal tip, the third microelectrode being mounted within the distal end of the first fluid delivery device movable between an insertion configuration in which the third distal tip thereof is received within the first fluid delivery device and a deployed configuration in which the third distal tip of the third microelectrode penetrates the pia mater to a third electrode target position in the cerebral cortex; and

a fifth fluid lumen extending through the first fluid delivery device from the first fluid lumen proximal end to a third outlet opening which, when the first fluid delivery device is at the first target site, opens to a third target location.

5. The apparatus of claim 4 , further comprising a sixth fluid lumen extending through the first fluid delivery device from the second fluid lumen proximal end to the third outlet opening.

6. The apparatus of claim 5 , wherein the third electrode target position corresponds to the third target location.

7. The apparatus of claim 6 , wherein the first, third and fifth fluid lumens extend through the first fluid delivery device to a source of therapeutic agent and the second, fourth and sixth fluid lumens extend through the first fluid delivery device to a source of one of artificial cerebrospinal fluid and saline.

8. The apparatus of claim 7 , wherein the lengths of the first, second, third, fourth, fifth and sixth fluid lumens are substantially equal to one another.

9. The apparatus of claim 8 , wherein the first and second fluid lumens extend along a first winding path to reach the first outlet opening and the third and fourth fluid lumens extend along a second winding path to reach the second outlet opening, each of the first and second winding paths having a length equal to that of a third path along which the fifth and sixth fluid lumens extend to the third outlet opening.

10. The apparatus of claim 7 , further comprising a controller analyzing data received from the first, second and third microelectrodes and, when a predetermined target brain activity is detected, supplying to the first, second and third target positions one of a therapeutic agent and a neutral agent.

11. The apparatus of claim 10 , wherein the neutral agent includes one of artificial cerebrospinal fluid and saline.

12. The apparatus of claim 4 , wherein the first, second and third microelectrodes extend distally from a single branching electrode.

13. The apparatus of claim 4 , wherein the first microelectrode further includes a second distal tip which, when in the insertion position, is received within the first fluid delivery device and which, when in the deployed position, extends out of the first fluid delivery device to penetrate the pia mater at a second first electrode target position in the cerebral cortex.

14. The apparatus of claim 13 , wherein the first microelectrode further includes a third distal tip which, when in the insertion position, is received within the first fluid delivery device and which, when in the deployed position, extends out of the first fluid delivery device to penetrate the pia mater at a third first electrode target position in the cerebral cortex.

15. The apparatus of claim 4 , further comprising a canal formed in the first fluid delivery device to house the first, second and third microelectrodes therein when in the insertion position.

16. The apparatus of claim 15 , wherein the canal is formed of one of fused silica and Teflon.

17. The apparatus of claim 15 , wherein the canal is angularly shaped to allow the first, second and third microelectrodes to exit at an angle of between 10 degrees to 30 degrees with respect to a surface of the pia mater.

18. The apparatus of claim 4 , wherein the first, second and third microelectrodes detect one of an EEG signal and multi-neuronal activity in the brain.

19. The apparatus of claim 4 , further comprising:

a second fluid delivery device including a distal end sized and shaped for placement at a second target site between the dura mater and the pia mater of the brain, the second fluid delivery device including a seventh fluid lumen extending to a fourth outlet opening in the distal end to deliver fluids to a second target location; and

a fourth microelectrode mounted within the distal end of the second fluid delivery device for movement between an insertion position in which a first distal tip of the fourth microelectrode is received within the second fluid delivery device and a deployed position in which the fourth microelectrode extends out of the second fluid delivery device with the first distal tip thereof penetrating the pia mater to a first fourth electrode target position in the cerebral cortex.

20. The apparatus of claim 2 , wherein the second electrode target position corresponds to the second target location.

21. The apparatus of claim 1 , further comprising a laser-perforated disk disposed over an opening of the first outlet opening.

22. The apparatus of claim 21 , wherein the laser-perforated disk is formed of an MRI-compatible material.

23. The apparatus of claim 21 , wherein the laser-perforated disk comprises 5,000-60,000 perforations.

24. The apparatus of claim 21 , further comprising a silicone rim formed around a periphery of the laser-perforated disk, the silicone rim adapted to prevent a spillover of fluids from the perforated disk to non-targeted locations.