Phospholipid analogs as diapeutic agents and methods thereof
The present invention provides methods and uses of phospholipid ether analogs as diagnostic and therapeutic agents for numerous cancers.
1. A method for the treatment of a cancer in a subject comprising:
administering, to the subject, an effective amount of 18-(p-iodophenyl)octadecyl phosphocholine for treating the cancer, wherein the iodo moiety of the 18-(p-iodophenyl)octadecyl phosphocholine is 125 I or 131 I, and wherein the cancer is intestinal cancer, adrenal cancer, liver cancer, subcutaneous cancer, retinoblastoma, cervical cancer, brain cancer, bladder cancer, or leukemia.
2. The method of claim 1 , wherein the iodo moiety is 125 I.
3. The method of claim 1 , wherein the iodo moiety is 131 I.
4. The method of claim 1 , comprising administering 5-20 μCi/200 g of body weight of the 18-(p-iodophenyl)octadecyl phosphocholine to the subject.
5. The method of claim 1 , comprising administering 15-20 μCi/200 g of body weight of the 18-(p-iodophenyl)octadecyl phosphocholine to the subject.
6. The method of claim 1 , wherein the subject is human.
7. The method of claim 1 , wherein the cancer is intestinal cancer.
8. The method of claim 1 , wherein the cancer is adrenal cancer.
9. The method of claim 1 , wherein the cancer is liver cancer.
10. The method of claim 1 , wherein the cancer is subcutaneous cancer.
11. The method of claim 1 , wherein the cancer is retinoblastoma.
12. The method of claim 1 , wherein the cancer is cervical cancer.
13. The method of claim 1 , wherein the cancer is brain cancer.
14. The method of claim 1 , wherein the cancer is bladder cancer.
15. The method of claim 1 , wherein the cancer is leukemia.