Methods for treating chronic obstructive pulmonary disease
View Patent ↗Methods and compositions that down regulate the activity of orexins to treat panic disorder and panic-like responses associated with hypercapnic conditions are disclosed.
1. A method of treating hypercapnia-induced anxiety associated with chronic obstructive pulmonary disease in an individual, the method comprising administering to the individual suffering from chronic obstructive pulmonary disease a composition comprising a therapeutically effective amount of an agent to down regulate the activity of an orexin, Orexin A, wherein the agent is an orexin receptor antagonist for orexin 1 receptors; wherein the effective amount treats hypercapnia-induced anxiety associated with chronic obstructive pulmonary disease in the individual wherein the effective amount treats hypercapnia-induced anxiety without altering the robust bradycardia response.
2. The method of claim 1 , wherein the orexin receptor antagonist is selected from SB334867, and SB408124.
3. The method of claim 1 , wherein the orexin receptor antagonist comprises about 30 mg/kg.
4. The method of claim 1 , wherein the orexin receptor antagonist is administered by a route selected from the group consisting of orally and parenterally.
5. The method of claim 1 , wherein the orexin receptor antagonist is administered by a route selected from the group consisting of intranasally, inhalable, intramuscularly, intraperitoneally; intravenously, intraventricularly, intraspinally, intrarectally, ipsalaterally and subcutaneously.