Antibody combinations and use of same for treating cancer
A method of identifying a combination of antibodies with a combined improved anti-tumor activity is provided. The method comprising: (a) identifying binding epitopes of anti ErbB-2 antibodies; and (b) selecting a combination of at least two antibodies of the anti ErbB-2 antibodies exhibiting binding to different epitopes on the ErbB-2, at least one of the different epitopes being localized to a dimerization site of the ErbB-2, the combination of antibodies being with the combined improved anti-tumor activity. Also provided are novel antibody combinations uncovered according to the present teachings.
1. A method of treating gastric cancer in a subject in need thereof, the method comprising administering to the subject an antibody combination with a combined improved anti-tumor activity selected from the group consisting of:
an anti-ErbB-2 antibody comprising the CDR sequences of N12 deposit number CNCM I-4112 and an anti-ErbB-2 antibody comprising the CDR sequences of L431 deposit number CNCM I-4115;
an anti-ErbB-2 antibody comprising the CDR sequences of N29 deposit number CNCM I-4114 and an anti-ErbB-2 antibody comprising the CDR sequences of L26 deposit number CNCM I-4113;
an anti-ErbB-2 antibody comprising the CDR sequences of N29 deposit number CNCM I-4114 and an anti-ErbB-2 antibody comprising the CDR sequences of N12 deposit number CNCM I-4112; and
an anti-ErbB-2 antibody comprising the CDR sequences of N29 deposit number CNCM I-4114 and an anti-ErbB-2 antibody comprising the CDR sequences of L431 deposit number CNCM I-4115.
2. A method of treating gastric cancer in a subject in need thereof, the method comprising administering to the subject an anti-ErbB-2 antibody comprising the CDR sequences of N12 deposit number CNCM I-4112 and an anti-ErbB-2 antibody comprising the CDR sequences of L431 deposit number CNCM I-4115, wherein the combination of antibodies being with a combined improved anti-tumor activity.
3. A method of treating pancreatic carcinoma in a subject in need thereof, the method comprising administering to the subject an anti-ErbB-2 antibody comprising the CDR sequences of N12 deposit number CNCM I-4112 and an anti-ErbB-2 antibody comprising the CDR sequences of L431 deposit number CNCM I-4115, wherein the combination of antibodies being with a combined improved anti-tumor activity.