Metal oxide coating on surfaces
The present invention provides a method for coating metal oxide on a PDMS surface. The method includes preparing a mixture that contains a sol-gel precursor, reacting the mixture to form a preconverted sol-gel precursor, where the preconverted sol-gel precursor does not diffuse into PDMS and is not in the form of a gel, forming a reactive PDMS surface, applying the preconverted sol-gel precursor onto the reactive PDMS surface, binding the preconverted sol-gel precursor to the re-active PDMS surface, and converting the bound preconverted sol-gel precursor to a metal oxide to form a metal oxide coating on the PDMS surface. The present invention also provides a PDMS microfluidic device where one or more channels of the microfluidic device is provided with a metal oxide coating covalently bound only on the surface of the one or more channels.
1. A microfluidic device comprising:
one or more channels defined by at least one surface; and
a non-porous metal oxide coating covalently bound around the perimeter of the channel and only on the at least one surface that defines the one or more channels.
2. The microfluidic device of claim 1 , wherein the metal oxide coating comprises an oxide of a metal selected from the group consisting of aluminum, antimony, barium, bismuth, cadmium, calcium, cerium, cesium, chromium, cobalt, copper, dysprosium, erbium, gadolinium, germanium, hafnium, holmium, indium, iridium, iron, lanthanum, lead, lithium, lutetium, magnesium, manganese, molybdenum, neodymium, nickel, niobium, palladium, potassium, praseodymium, rhodium, rubidium, ruthenium, samarium, scandium, silicon, silver, sodium, strontium, tantalum, terbium, thallium, tin, titanium, tungsten, vanadium, ytterbium, yttrium, and zirconium.
3. The microfluidic device of claim 1 , wherein the channels are about 10 nm to about 1000 micrometers in size.
4. The microfluidic device of claim 1 , wherein the metal oxide coating is substantially free of cracks.
5. The microfluidic device of claim 1 , wherein the metal oxide comprises silica.
6. The microfluidic device of claim 1 , wherein the surface comprises a PDMS surface.
7. A microfluidic device comprising:
one or more channels defined by at least one surface; and
a metal oxide coating covalently bound only on the at least one surface that defines the one or more channels,
wherein at least part of the at least one surface on which the metal oxide coating is covalently bound comprises PDMS.
8. The microfluidic device of claim 7 , wherein the metal oxide coating comprises an oxide of a metal selected from the group consisting of aluminum, antimony, barium, bismuth, cadmium, calcium, cerium, cesium, chromium, cobalt, copper, dysprosium, erbium, gadolinium, germanium, hafnium, holmium, indium, iridium, iron, lanthanum, lead, lithium, lutetium, magnesium, manganese, molybdenum, neodymium, nickel, niobium, palladium, potassium, praseodymium, rhodium, rubidium, ruthenium, samarium, scandium, silicon, silver, sodium, strontium, tantalum, terbium, thallium, tin, titanium, tungsten, vanadium, ytterbium, yttrium, and zirconium.
9. The microfluidic device of claim 7 , wherein the channels are about 10 nm to about 1000 micrometers in size.
10. The microfluidic device of claim 7 , wherein the metal oxide coating is substantially free of cracks.
11. The microfluidic device of claim 7 , wherein the metal oxide comprises silica.