Medical devices with local drug delivery capabilities
A medical device, for example, an endoscope or catheter, includes local drug delivery capabilities for selectively delivering at least one drug in vivo. The local drug delivery may occur as the medical device is advanced through tortuous passageways of the patient's body or may occur after the medical device has reached its targeted destination. The medical device includes a drug agent, for example, carried in or on a hydrophilic or hydrogel coating disposed on the outside thereof. When the hydrogel or drug agent receives an appropriate signal, e.g., solution containing a triggering agent or triggering condition, e.g., heat or light, the hydrogel contracts or expands to squeeze out the drug from hydrogel. If electric current is provided as the signal, and the drug agent is charged, the drug agent is released by electrophoretic forces.
1. A method of selectively releasing an analgesic drug agent from an endoscope in vivo, said method comprising:
routing an endoscope through an intestinal tract of a patient's body, wherein said endoscope comprises: (a) a shaft having proximal and distal ends, a working channel lumen, and an outer surface; (b) a hydrogel outermost layer disposed on a portion of the outer surface of the shaft; (c) an analgesic drug agent carried in or on a portion of the hydrogel outermost layer; (d) three or more electrodes spaced apart along a length of the endoscope in contact with the outermost layer, wherein each of the electrodes is adapted to be individually selectively energized; and (e) a stimulus generator associated with the endoscope, the stimulus generator, based upon a selective input, generating an electrical stimulus that causes the drug agent to be released from the hydrogel outermost layer; and
selectively energizing said electrodes to release the analgesic drug agent from the hydrogel outermost layer, wherein the analgesic drug agent is delivered locally to a wall of the intestinal tract for relieving patient discomfort.
2. The method of claim 1 , wherein selectively releasing of the drug agent includes user input.
3. The method of claim 1 , wherein selectively releasing the drug agent includes input based upon environmental conditions.