Dendrimer conjugates
The present invention relates to novel therapeutic and diagnostic dendrimers. In particular, the present invention is directed to dendrimer-linker conjugates, methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer-linker conjugates of the present invention may further comprise one or more components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy.
1. A composition comprising pain relief complexes and pain relief antagonist complexes;
wherein said pain relief complexes consist of dendrimers separately conjugated with 1) a pain relief agent via an ester linkage agent, wherein said pain relief agent is morphine, 2) a locking agent, wherein said locking agent is trigonelline, and 3) a targeting agent, wherein said targeting agent is transferrin;
wherein said pain relief antagonist complexes consist of dendrimers separately conjugated with 1) a pain relief agent antagonist via an indolequinone trigger agent, wherein said pain relief agent antagonist is naloxone, 2) a locking agent, wherein said locking agent is trigonelline, and 3) a targeting agent, wherein said targeting agent is transferrin;
wherein said pain relief antagonist complexes are configured to prevent respiratory depression caused said pain relief complexes;
wherein said dendrimers within said pain relief complexes and pain relief antagonist complexes are separate within said composition.
2. The composition of claim 1 , wherein said dendrimers are selected from the group consisting of a polyamideamine (PAMAM) dendrimer, a polypropylamine (POPAM) dendrimer, and a PAMAM-POPAM dendrimer.
3. The composition of claim 1 , wherein the linkage agent comprises a spacer comprising between 1 and 8 straight or branched carbon chains, wherein said straight or branched chains are selected from the group consisting of i) unsubstituted, and ii) substituted with alkyls.
4. The composition of claim 1 , wherein said dendrimers are acetylated.