IP Library › Granted Patent US 8,895,263
Granted Patent B2
US 8,895,263 · App. 12/572,338 · Granted Nov 25, 2014

Methods for suppressing toll-like receptor activity

Inventors: Jarrat Jordan (Radnor, PA); Sun-Yung Jung (Radnor, PA); Robert T. Sarisky (Yardley, PA); Jessica Schreiter (Radnor, PA)
Assignee: Janssen Biotech, Inc.
C07K16/2896A61K2039/505A61K38/177
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Quick Facts
Patent No.
US 8,895,263
App. No.
12/572,338
Granted
Nov 25, 2014
Kind
B2
Abstract

Agents interfering with translocation of Toll-like receptor 3 (TLR3), methods of making and using the foregoing are disclosed.

Claims (6)

1. A method of interfering with translocation of toll-like receptor 3 (TLR3) in vitro, comprising transfecting into a cell expressing TLR3 a cDNA that encodes an agent that interferes with translocation of TLR3, wherein the agent is a TLR3 variant comprising a polypeptide having the amino acid sequence shown in SEQ ID NO: 1 or SEQ ID NO: 2.

2. The method of claim 1 , wherein the cell is a HEK293T cell.

3. The method of claim 1 , wherein the agent interferes with surface expression of TLR3.

4. The method of claim 1 , wherein the agent interferes with translocation of TLR3 from the endoplasmic reticulum.

5. The method of claim 1 , wherein the agent interferes with translocation of TLR3 to the endosome.

6. The method of claim 1 , wherein the agent interferes with co-localization of TLR3 with its ligand.

Assignments (1)
CHANGE OF NAME Recorded Sep 15, 2014
From: CENTOCOR ORTHO BIOTECH INC.
To: JANSSEN BIOTECH, INC.
Reel/Frame 033744/0331 →
Continuity (2)
Provisional Application 61102033 · Oct 2, 2008
Related Publication 20100092462A1 · Apr 15, 2010