Compositions and methods for treating cardiovascular diseases

1. A pharmaceutical composition comprising:

a) a therapeutic compound, wherein the therapeutic compound has an activity that normalizes lipid levels;

b) about 1% (v/v) to about 10% (v/v) of a pharmaceutically-acceptable solvent; and

c) at least 85% (v/v) of a pharmaceutically-acceptable lipid-adjuvant,

wherein the pharmaceutically-acceptable lipid-adjuvant is a fatty acid having at least 12 carbons, a glycerolipid, a sphingolipid, a sterol lipid, a prenol lipid, a saccharolipid, or a polyketide,

wherein the pharmaceutical composition is formulated to be a solid at a temperature of about 15° C. or lower.

2. The pharmaceutical composition according to claim 1 , wherein the activity that normalizes lipid levels has an anti-hyperlipidemia activity.

3. The pharmaceutical composition according to claim 1 , wherein the activity that normalizes lipid levels reduces the level of an inflammation inducing prostaglandin.

4. The pharmaceutical composition according claim 1 , wherein the activity that normalizes lipid levels stimulates a PPAR signaling pathway.

5. The pharmaceutical composition according to claim 1 , wherein the activity that normalizes lipid levels induces apoptosis of Macrophage M1 cells, promotes differentiation of Macrophage M2 cells, or both.

6. The pharmaceutical composition according to claim 1 , wherein the activity that normalizes lipid levels reduces the levels of Interferon-gamma (IFNy), Tumor necrosis factor-alpha (TNF-α), Interleukin-12 (IL-12), or a combination thereof released from Th1 cells, increases the levels of IL-10 released from a Th2 cell, or both.

7. The pharmaceutical composition according to claim 1 , wherein the activity that normalizes lipid levels reduces the level of an inflammation inducing molecule.

8. The pharmaceutical composition according to claim 1 , wherein the therapeutic compound comprises a non-steroidal anti-inflammatory drug (NSAID).

9. The pharmaceutical composition according to claim 8 , wherein the NSAID comprises a salicylate derivative NSAID, a p-amino phenol derivative NSAID, a propionic acid derivative NSAID, an acetic acid derivative NSAID, an enolic acid derivative NSAID, a fenamic acid derivative NSAID, a non-selective cyclo-oxygenase inhibitor, a selective cyclooxygenase 1 inhibitor, a selective cyclooxygenase 2 inhibitor or a combination thereof.

10. The pharmaceutical composition according to claim 1 , wherein the therapeutic compound comprises a PPARγ agonist.

11. The pharmaceutical composition according to claim 10 , wherein the PPARγ agonist comprises Monascin, Irbesartan, Telmisartan, mycophenolic acid, Resveratrol, Delta(9)-tetrahydrocannabinol, a cannabidiol, Curcumin, Cilostazol, Benzbromarone, 6-shogaol, glycyrrhetinic acid, a thiazolidinedione, a NSAID, a fibrate, or a combination thereof.

12. The pharmaceutical composition according to claim 1 , wherein the therapeutic compound comprises a nuclear receptor binding agent.

13. The pharmaceutical composition according to claim 12 , wherein the nuclear receptor binding agent comprises a Retinoic Acid Receptor (RAR) binding agent, a Retinoid X Receptor (RXR) binding agent, a Liver X Receptor (LXR) binding agent, a Vitamin D binding agent, or a combination thereof.

14. The pharmaceutical composition according to claim 1 , wherein the therapeutic compound comprises an anti-hyperlipidemic agent.

15. The pharmaceutical composition according to claim 14 , wherein the anti-hyperlipidemic agent comprises a fibrate, a statin, a tocotrienol, a niacin, a bile acid sequestrants, a cholesterol absorption inhibitor, a pancreatic lipase inhibitor, a sympathomimetic amine, or a combination thereof.

16. The pharmaceutical composition according to claim 1 , wherein the therapeutic compound comprises an ester of a therapeutic compound.

17. The pharmaceutical composition according to claim 1 , wherein the therapeutic compound comprises an ester of the therapeutic compound.

18. The pharmaceutical composition according to claim 1 , wherein the pharmaceutically-acceptable solvent is less than about 5% (v/v).

19. The pharmaceutical composition according to claim 1 , wherein the pharmaceutically-acceptable solvent comprises a pharmaceutically-acceptable polar aprotic solvent, a pharmaceutically-acceptable polar protic solvent, a pharmaceutically-acceptable non-polar solvent, or a combination thereof.

20. The pharmaceutical composition according to claim 1 , wherein the pharmaceutically-acceptable solvent comprises a pharmaceutically-acceptable alcohol.

21. The pharmaceutical composition according to claim 1 , wherein the pharmaceutically-acceptable solvent comprises a pharmaceutically-acceptable ester of pharmaceutically-acceptable alcohol and an acid.

22. The pharmaceutical composition according to claim 1 , wherein the adjuvant is at least 90% (v/v).

23. The pharmaceutical composition according to claim 1 , wherein the pharmaceutically-acceptable adjuvant comprises a pharmaceutically-acceptable lipid.

24. The pharmaceutical composition according to claim 23 , wherein the pharmaceutically-acceptable lipid comprises a saturated fatty acid, an unsaturated fatty acid, or a combination thereof.

25. The pharmaceutical composition according to claim 23 , wherein the pharmaceutically-acceptable lipid comprises a pharmaceutically-acceptable oil.

26. The pharmaceutical composition according to claim 1 , wherein the pharmaceutical composition further comprises a pharmaceutically-acceptable stabilizing agent, wherein the pharmaceutically-acceptable stabilizing agent is not an emulsifying agent.

27. The pharmaceutical composition according to claim 26 , wherein the pharmaceutically-acceptable stabilizing agent comprises water, a sacrificial acid comprising a fatty acid component and acetic acid, ethyl acetate, a sodium acetate/acetic acid, a monoglyceride, an acetylated monoglyceride, a diglyceride, an acetylated diglyceride, a fatty acid, a fatty acid salt, or a combination thereof.

28. A method of treating an individual with a cardiovascular disease, the method comprising the step of: administering to the individual in need thereof a pharmaceutical composition according to claim 1 , wherein administration results in a reduction in a symptom associated with the cardiovascular disease, thereby treating the individual.

29. The method according to claim 28 , wherein the cardiovascular disease is associated with a hyperlipidemia, a coronary heart disease, an atherosclerosis, a peripheral vascular disease, a cardiomyopathy, a vasculitis, an inflammatory heart disease, an ischemic heart disease, a congestive heart failure, a hypertensive heart disease, a valvular heart disease, a hypertension, myocardial infarction, a diabetic cardiac conditions, an aneurysm; an embolism, a dissection, a pseudoaneurysm, a vascular malformation, a vascular nevus, a thrombosis, a varicose vein, or a stroke.

30. The method according to claim 28 , wherein upon administration to the individual, the pharmaceutical composition comprising the therapeutic compound results in a bio-distribution of the therapeutic compound different than a bio-distribution of the therapeutic compound included in the same pharmaceutical composition, except without the pharmaceutically-acceptable adjuvant.

31. The method according to claim 28 , wherein upon administration to the individual, the pharmaceutical composition reduces gastric or intestinal irritation by at least 5% when compared to the pharmaceutical composition, except without the pharmaceutically-acceptable adjuvant.