Hybrid SCFA-hydroxyl-derivatized monosaccharides, methods of synthesis, and methods of treating disorders
Described herein are fatty acid carbohydrate-hydroxyl-hybrid compounds and derivatives thereof, and methods of treating or preventing disease and disease symptoms using the compounds and compositions thereof.
1. A compound of formula I, or pharmaceutically acceptable salt thereof:
wherein,
R 1 is H and each of R 2 , R 3 and R 4 is independently —C(O)(CH 2 ) n CH 3 wherein each n is independently an integer from 1-18; and
R is alkyl or alkenyl, each of which is optionally substituted with 1-4 substituents selected from acyl, oxo, azido, aryl, —OC(O)alkyl, or —SC(O)alkyl.
2. A compound of formula II or formula IV, or pharmaceutically acceptable salt thereof:
wherein,
R 1 is H and each of R 2 , R 3 and R 4 is independently —C(O)(CH 2 ) n CH 3 wherein each n is independently an integer from 1-18; and
R is alkyl or alkenyl, each of which is optionally substituted with 1-4 substituents selected from acyl, oxo, azido, aryl, halogen, —OC(O)alkyl, or —SC(O)alkyl.
3. The compound of claim 2 , wherein each of R 2 , R 3 and R 4 is —C(O)(CH 2 ) 2 CH 3 .
4. The compound of claim 2 , wherein R is alkyl or a substituted alkyl which may be substituted by oxo, azido, aryl, halogen, —OC(O)alkyl, or —SC(O)alkyl.
5. The compound of claim 1 , of formula III, or pharmaceutically acceptable salt thereof:
wherein,
R 1 is H and each of R 2 , R 3 and R 4 is independently —C(O)(CH 2 ) n CH 3 wherein each n is independently an integer from 1-18; and
R is alkyl or alkenyl, each of which is optionally substituted with 1-4 substituents selected from acyl, oxo, azido, aryl, OC(O)alkyl, or —SC(O)alkyl.
6. A pharmaceutical composition comprising a compound of claim 1 and a pharmaceutically acceptable carrier.
7. The composition of claim 6 , further comprising an additional therapeutic agent.
8. A kit comprising an effective amount of a compound of claim 1 in unit dosage form, together with instructions for administering the compound to a subject suffering from or susceptible to a cancer disease or disorder or symptoms thereof.