IP Library › Granted Patent US 8,933,233
Granted Patent B2
US 8,933,233 · App. 13/853,443 · Granted Jan 13, 2015

1,3,4-oxadiazole and 1,3,4-thiadiazole β-lactamase inhibitors

Inventors: Yu Gui Gu (Acton, MA); Yong He (Bedford, MA); Ning Yin (Lexington, MA); Dylan C. Alexander (Watertown, MA); Jason B. Cross (Acton, MA); Chester A. Metcalf, III (Needham, MA)
Assignee: Cubist Pharmaceuticals, Inc.
A61K31/546A61K31/545A61K31/407A61K45/06C07D471/08A61K31/436A61K31/439A61K31/427
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Quick Facts
Patent No.
US 8,933,233
App. No.
13/853,443
Granted
Jan 13, 2015
Kind
B2
Abstract

β-Lactamase inhibitor compounds (BLIs) are disclosed, including compounds that have activity against class A, class C or class D β-lactamases. Methods of manufacturing the BLIs, and uses of the compounds in the preparation of pharmaceutical compositions and antibacterial applications are also disclosed.

Claims (6)

1. A compound of the formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutical composition comprising a compound of claim 1 and at least 1 β-lactam antibiotic.

3. The pharmaceutical composition of claim 2 wherein the β-lactam antibiotic is a cephalosporin.

4. The pharmaceutical composition of claim 2 wherein the β-lactam antibiotic is a carbapenem.

5. The pharmaceutical composition of claim 2 wherein the β-lactam antibiotic is a monobactam.

Assignments (6)
MERGER Recorded Aug 8, 2022
From: MERCK SHARP & DOHME CORP.
To: MERCK SHARP & DOHME LLC
Reel/Frame 061102/0145 →
NUNC PRO TUNC ASSIGNMENT Recorded Aug 6, 2015
From: CUBIST PHARMACEUTICALS LLC
To: MERCK SHARP & DOHME CORP.
Reel/Frame 036268/0626 →
CHANGE OF NAME Recorded Aug 5, 2015
From: CUBIST PHARMACEUTICALS, INC.
To: CUBIST PHARMACEUTICALS LLC
Reel/Frame 036283/0189 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2014
From: GU, YU GUI; HE, YONG; YIN, NING; ALEXANDER, DYLAN C.; CROSS, JASON B.; METCALF, CHESTER A., III; BUSCH, ROBERT
To: CUBIST PHARMACEUTICALS, INC.
Reel/Frame 031983/0695 →
CORRECTIVE ASSIGNMENT TO CORRECT THE PROPERTY NUMBERS 61/618,131 RECORDED ON REEL 030839 FRAME 0513. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Nov 14, 2013
From: GU, YU GUI; HE, YONG; YIN, NING; ALEXANDER, DYLAN C; CROSS, JASON B; METCALF III, CHESTER A; BUSCH, ROBER
To: CUBIST PHARMACEUTICALS, INC.
Reel/Frame 031872/0853 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jul 19, 2013
From: GU, YU GUI; HE, YONG; YIN, NING; ALEXANDER, DYLAN C.; CROSS, JASON B.; METCALF, CHESTER A., III; BUSCH, ROBERT
To: CUBIST PHARMACEUTICALS, INC.
Reel/Frame 030839/0513 →
Continuity (3)
Provisional Application 61618131 · Mar 30, 2012
Provisional Application 61790579 · Mar 15, 2013
Related Publication 20130303504A1 · Nov 14, 2013