Modulating the alternative complement pathway
View Patent ↗Provided herein are compositions, including pharmaceutical compositions, and methods for modulating, i.e., stimulating or inhibiting, activity of the alternative complement pathway, and methods of identifying factor H-binding proteins.
1. A method of treating a pathogen infection in an individual in need thereof, comprising administering to the individual a composition in an amount effective to stimulate the alternative complement pathway activity in said individual, said composition comprising annexin A2 or a biologically-active fragment thereof, wherein said pathogen is a cell susceptible to osmolytic pore formation by the membrane attack complex of the alternative complement pathway, thereby treating said pathogen infection.
2. The method of claim 1 , wherein the individual is a mammal.
3. The method of claim 2 , wherein the mammal is a human, a mouse, or a rat.
4. The method of claim 1 , wherein the individual is administered a composition comprising annexin A2.
5. The method claim 4 , wherein the composition is administered orally or by injection.
6. The method of claim 5 , wherein the injection is intravenous.