Compositions and methods of treating retinal disease

1. A compound of formula IIIa:

or a pharmaceutically acceptable salt thereof, wherein:

A is

B is a halogen atom, hydroxyl, carbamoyl, aryl or amino;

p is 0, 1, 2, or 3;

D is unbranched lower alkyl;

L is a single bond or CH 2 ; and

X, Y, and Z are each, independently, N, NH, O, S, CB, CH, or absent, such that at least one of X, Y, and Z is N or NH; wherein X, Y, and Z and the carbon atoms to which they are attached form a 5- or 6-membered optionally substituted heterocyclic ring.

2. The compound of claim 1 ,

or a pharmaceutically acceptable salt thereof,

wherein

one of X or Z is N and the remaining X or Z is O;

Y is absent; such that X and Z and the carbon atoms to which they are attached form a 5-membered heterocyclic ring; and

p is 1.

3. The compound of claim 2 , wherein L is a single bond.

4. The compound of claim 3 , wherein X is O and Z is N.

5. The compound of claim 3 , wherein X is N and Z is O.

6. The compound of claim 4 or 5 , wherein B is aryl.

7. The compound of claim 6 , wherein B is phenyl.

8. The compound of claim 3 , wherein D is CH 3 .

9. The compound of claim 8 selected from

and

pharmaceutically acceptable salts thereof.

10. A pharmaceutical composition comprising a compound of claim 1

or a pharmaceutically acceptable salt thereof,

and a pharmaceutically acceptable carrier.

11. The pharmaceutical composition of claim 10 comprising a compound, which is

or a pharmaceutically acceptable salt thereof.

12. The pharmaceutical composition of claim 10 comprising a compound, which is

or a pharmaceutically acceptable salt thereof.

13. The pharmaceutical composition of claim 10 comprising a compound selected from

or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable carrier.

14. A compound, which is

or a pharmaceutically acceptable salt thereof.

15. A compound, which is

or a pharmaceutically acceptable salt thereof.