Medical devices incorporating ceragenin-containing composites
A medical device that includes a coating of a composite material that includes a polymeric material having a void structure and particulate ceragenin material (i.e., ceragenin particles) associated with the void structure. The average particle size of the ceragenin particles in the composite is in a range from 5 nm to 20 μm, 50 nm to 10 μm, 100 nm to 5 Ξm, or 1 μm to 10 μm. The composite has a high loading of ceragenin particles (e.g., about 10% to about 25%, by weight). The composite has good polymer stability, the ability to release ceragenins from the ceragenin particles disposed in the composite over a sustained period of time at a characteristic elution rate, and the ability to kill large numbers of bacteria and other susceptible microbes over the sustained period of time.
1. A medical device, comprising
an implantable body; and
a composite coated on at least a portion of the implantable body, the composite comprising a polymeric material having ceragenin particles comprised of at least one type of ceragenin compound dispersed therein,
wherein the ceragenin particles each comprise a cluster of ceragenin molecules,
wherein the ceragenin particles are disposed in a void structure in the polymeric material,
wherein the ceragenin particles comprise 1 wt % to 25 wt % of the composite.
2. The medical device of claim 1 , wherein the polymeric material is selected from the group consisting of a silicone polymer, a vinyl polymer, a urethane polymer, a methacrylate polymer, a polyester, and combinations thereof.
3. The medical device of claim 1 , wherein the composite coated on at least the portion of the implantable body has a thickness less than 500 μm and greater than 1 μm.
4. The medical device of claim 1 , wherein the composite includes 16 wt % to 20 wt % ceragenin particles.
5. The medical device of claim 1 , wherein the ceragenin particles have an average particle size in a range from 5 nanometers (“nm”) to 20 micrometers (“μm”).
6. The medical device of claim 1 , wherein the void structure is formed by the ceragenin particles.
7. The medical device of claim 6 , wherein the void structure includes pores having a size in a range from 5 nm to 20 μm.
8. The medical device of claim 1 , wherein the composite coated on at least a portion of the implantable body is configured to elute at least one ceragenin molecule when the implantable body contacts an aqueous environment.
9. The medical device of claim 1 formed according to a method comprising:
providing the implantable body;
providing a ceragenin mixture that includes the ceragenin particles dispersed in a dispersant;
dispersing the ceragenin mixture in a polymerizable material to form a polymerizable mixture;
applying the polymerizable mixture to at least a portion of the implantable body to form a coating; and
polymerizing the polymerizable material to yield the composite coated on at least the portion of the implantable body.
10. The medical device of claim 9 , wherein the applying includes at least one of brush coating, dip coating, electrospray coating, spin coating, melt spinning, or electro spinning.
11. The medical device of claim 9 , wherein the polymerizable mixture has a viscosity in a range from about 500 mPa·s to about 6000 mPa·s.
12. The medical device of claim 9 , wherein the polymerizable mixture has a viscosity in a range from about 10 mPa·s to about 10,000 mPa·s so as to be suitable for at least one of brush coating, dip coating, electrospray coating, spin coating, melt spinning, or electro spinning.
13. The medical device of claim 9 , wherein the composite coated on at least the portion of the implantable body has a thickness that is at least 2.5 to 100 times greater than an average diameter of the plurality of ceragenin particles.
14. The medical device of claim 9 , wherein the dispersant is selected from the group consisting of naphtha, xylenes, pentane, cyclopentane, hexanes, cyclohexane, benzene, toluene, dioxane, chloroform, diethyl ether, dichloromethane, and combinations thereof.
15. The medical device of claim 9 , the method further comprising sterilizing the implantable body with at least one of temperature, pressure, radiation, or a chemical agent after polymerizing the polymerizable material to yield the composite.
16. The medical device of claim 9 , wherein the polymerizable material is selected from the group consisting of a precursor of a silicone polymer, a vinyl polymer, a urethane polymer, a methacrylate polymer, a polyester, and combinations thereof.
17. A method of treating an infection, comprising:
providing a medical device as in claim 1 ;
implanting the implantable body in an animal body;
eluting at least one ceragenin compound from the ceragenin particles into the animal body; and
killing one or more microbes in the animal body.
18. The method of claim 17 , wherein the one or more microbes comprise a biofilm.
19. The method of claim 17 , wherein the at least one ceragenin compound eluted from the ceragenin particles is sufficient to continue killing microbes for at least 1-15 days after implanting the implantable device in the body.
20. The method of claim 17 , wherein the animal body is a human body.
21. A medical device, comprising
an implantable body; and
a composite coated on at least a portion of the implantable body, the composite comprising a polymeric material having ceragenin particles comprised of at least one type of ceragenin compound dispersed therein,
wherein the ceragenin particles each comprise a cluster of ceragenin molecules,
wherein the ceragenin particles are disposed in a void structure in the polymeric material,
wherein the void structure is selected so as to assist elution of ceragenin molecules from the composite during use; and
wherein the ceragenin particles comprise up to 35 wt % of the composite.