Photoinitiated tissue filler
Visible light-activated polymer cosmetic filler preparations useful in a variety of applications are provided. In some embodiments, the photo-activated polymer composition comprises a conventional polymeric material, such as HA, together with a modified, crosslinkable polymer, such as PEG or PEODA, to permit the formation of crosslinks within the polymer matrix in situ on exposure to a visible light source, such as an IPL device. The preparations provide for a more stabilized composition that is contourable during gelation.
1. A method of filling a tissue space under the epidermis comprising:
a) introducing a polymer solution into the tissue space comprising:
i) a modified hyaluronic acid consisting of a Non Animal Stabilized Hyaluronic Acid having a molecular weight of about 1 million, and stabilized by 1,4-Butanediol Diglycidyl Ether (BDDE);
ii) PEGDA and/or PEODA having a molecular weight of between about 2000 to 3400 daltons;
iii) N-vinyl pyrrolidinone;
iv) at least one initiator;
wherein the ratio of PEGDA and/or PEODA to modified hyaluronic acid in w/w is from about 5:1 to 10:1; and
b) applying visible light to the surface of the epidermis superficial to said space to induce polymerization.
2. The method of claim 1 , wherein said visible light is provided by an IPL device.
3. The method of claim 2 , wherein said device is placed 1 cm above the epidermis.
4. The method of claim 2 , wherein said device is placed on the epidermis.
5. The method of claim 2 , wherein the PEGDA and/or PEODA has a molecular weight of about 3400.