Modulating the production of neurons and/or oligodendrocytes from white matter progenitor cells
The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
1. A method of increasing oligodendrocyte production from human glial progenitor cells, said method comprising:
providing a population of human glial progenitor cells and
administering in vitro to the provided population of human glial progenitor cells, an antagonist of receptor tyrosine phosphatase-β/ζ(RPTPZ), under conditions effective to increase oligodendrocyte production compared to oligodendrocyte production absent said administering.
2. The method of claim 1 , wherein the glial progenitor cells are oligodendrocyte progenitor cells.
3. The method of claim 1 , wherein the glial progenitor cells are from an adult human.
4. The method of claim 1 , wherein the antagonist is selected from the group consisting of bpV(HOpic), bpV(phen), bpV(pic), CDC25 Phosphatase Inhibitor BN82002, DMHV, Dephostatin, 3,4-Dephostatin, Phenylarsine Oxide, Protein Tyrosine Phosphatase CD45 Inhibitor, Protein Tyrosine Phosphatase Inhibitor I, Protein Tyrosine Phosphatase Inhibitor II, Protein Tyrosine Phosphatase Inhibitor III, Protein Tyrosine Phosphatase Inhibitor IV, RK-682, Sodium Stibogluconate, and bpV(bipy).
5. A method of increasing oligodendrocyte production from human glial progenitor cells, said method comprising:
providing a population of human glial progenitor cells and administering in vitro to the provided population of human glial progenitor cells, pleiotrophin (PTN), under conditions effective to increase oligodendrocyte production compared to oligodendrocyte production absent said administering.