Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases

1. A compound of general formula I,

wherein

R 1 is C 1-6 alkoxy, halogen, hydroxyl, monofluoromethoxy, difluoromethoxy, or trifluoromethoxy;

R 2 is cycloalkyl, alkylcycloalkyl, or cycloalkyl(C(O)NR 7 R 8 ), each of which is optionally substituted with one or more substituents selected from R 4 ;

R 3 is hydrogen, halogen, aryl, heteroaryl, hydroxy, alkyl, cycloalkyl, heterocycloalkyl, alkoxy, oxo, cyano, amino, aminoalkyl, alkylamino or dialkylamino;

R 4 is hydrogen, halogen, hydroxy, oxo, cyano, carboxy, or trihalomethyl, or R 4 is NR 5 R 6 , —C(O)NR 7 R 8 , —C(O)R 7 , —COOR 7 , —NR 5 C(O)NR 7 R 8 , —OC(O)NR 7 R 8 , —OC(O)R 3 , NC(O)R 7 , —OR 7 , —NC(O)OR 3 , —NSO 2 R 7 , —SO 2 NR 7 R 8 , or —SO 2 R 7 R 8 , alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, cycloalkenylalkyl, cycloalkenylalkenyl, cycloalkenylalkynyl, heterocycloalkyl, heterocycloalkylalkyl, heterocycloalkenyl, heterocycloalkenylalkyl, heterocycloalkenylalkenyl, heterocycloalkenylalkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, alkoxy, cycloalkyloxy, alkylthio, cycloalkylthio, sulfamoyl, sulfinamoyl, alkylamino or cycloalkylamino, each of which is optionally substituted with one or more substituents selected from R 9 ;

R 5 and R 6 each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, heterocycloalkyl, —C(O)alkyl, —C(O)Oalkyl, —C(O)cycloalkyl, —C(O)N-alkyl, carboxyalkyl, —C(O)alkyl-C(O)OH, —C(O)alkyl-C(O)N-alkyl, —C(O)N-aryl, —S(O) 2 alkyl, —S(O)alkyl, —S(O) 2 aryl, —S(O) 2 N-alkyl, —S(O)aryl, aryl, heteroaryl alkylaryl or alkylheteroaryl, each of which is optionally substituted with hydroxy or one or more halogens, or R 5 and R 6 together with the nitrogen atom to which they are attached form a heterocycloalkyl ring, wherein said ring is optionally substituted with one or more alkyl groups;

R 7 and R 8 each independently represents hydrogen, alkyl, cycloalkyl, alkenyl, heteroaryl, heterocycloalkyl, carboxyalkyl, carbamoylalkyl, alkyloxyalkyl, alkenyloxyalkyl, aryl, arylalkyl, alkylaryl, heteroaryl, heteroarylalkyl, or alkylheteroaryl, each of which is optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, oxo, cyano, alkyl, cycloalkyl, alkenyl, alkoxy, aryl, heteroaryl, heterocycloalkyl, —S(O) 2 -alkyl, —S(O) 2 —NR 11 R 12 , —NC(O)-alkyl, —C(O)N-alkyl, —NC(O)O-alkyl, —OC(O)N-alkyl, —NC(O)NR 11 R 12 , —NR 11 SO 2 -alkyl, —S(O)-alkyl, or R 7 and R 8 together with the nitrogen atom to which they are attached form a heterocycloalkyl ring, wherein said ring is optionally substituted with one or more alkyl groups;

R 9 is hydrogen, halogen, hydroxy, alkoxy, carboxy or trihalomethyl;

X and Y are either C and N or N and C, respectively;

A is aryl, heteroaryl, or piperidinyl, each being optionally substituted with one or more substituents selected from the group consisting of R 10 ;

R 10 is hydrogen, cyano, halogen, hydroxy, or oxo, or R 10 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkylalkyl, cycloalkylalkenyl, cycloalkylalkynyl, cycloalkenylalkyl, cycloalkenylalkenyl, cycloalkenylalkynyl, heterocycloalkyl, heterocycloalkenyl, heterocycloalkenylalkyl, heterocycloalkenylalkenyl, heterocycloalkenylalkynyl, arylalkyl, arylalkenyl, arylalkynyl, heteroarylalkyl, heteroarylalkenyl, heteroarylalkynyl, alkoxy, cycloalkyloxy, alkylthio, cycloalkylthio, —S(O)alkyl, —S(O) 2 -alkyl, sulfamoyl, sulfinamoyl, —C(O)OR 3 , —C(O)R 3 , —NR 5 R 6 , -alkyl(NR 5 R 6 ), -cycloalkyl(NR 5 R 6 ), -cycloalkylalkyl(NR 5 R 6 ), -alkylcycloalkyl(NR 5 R 6 ), —C(O)NR 7 R 8 , -alkyl(C(O)NR 7 R 8 ), -cycloalkyl(C(O)NR 7 R 8 ), -cycloalkylalkyl(C(O)NR 7 R 8 ) or -alkylcycloalkyl(C(O)NR 7 R 8 ), each of which is optionally substituted with one or more substituents selected from R 4 ; and

R 11 and R 12 each independently represents hydrogen or alkyl;

and pharmaceutically acceptable salts, hydrates, N-oxides or solvates thereof.

2. A compound according to claim 1 , wherein A is optionally substituted with R 10 , wherein R 10 is different from hydrogen.

3. A compound according to claim 1 , wherein A is optionally substituted aryl.

4. A compound according to claim 1 , wherein A is optionally substituted phenyl or optionally substituted indanyl.

5. A compound according to claim 4 , wherein R 10 is cyano, halogen, alkyl, aryl, heteroaryl, sulfamoyl, —C(O)R 3 , —C(O)OR 3 , —NR 5 R 6 , wherein R 3 , R 5 and R 6 are as indicated in claim 1 .

6. A compound according to claim 1 , wherein A is optionally substituted heteroaryl.

7. A compound according to claim 6 , wherein A is optionally substituted pyridyl, optionally substituted benzofuranyl, optionally substituted 3H-isobenzofuran-1-on-yl or optionally substituted 2,3-dihydro-isoindol-1-on-yl.

8. A compound according to claim 1 , wherein A is optionally substituted piperidinyl or optionally substituted pyridazinyl.

9. A compound according to claim 3 , wherein R 10 is hydrogen, cyano, halogen, oxo, alkyl, alkoxy, cycloalkyloxy, —S(O)alkyl, —S(O) 2 -alkyl, —C(O)R 3 , —C(O)OR 3 , —C(O)NR 7 R 8 .

10. A compound according to claim 9 , wherein R 10 is cyano, halogen, oxo, alkyl, alkoxy, or —C(O)R 3 .

11. A compound according to claim 1 , wherein R 1 is methoxy, monofluoromethoxy, difluoromethoxy, trifluoromethoxy, halogen, or hydroxy.

12. A compound according to claim 1 , of general formula Ia

wherein R 1 , R 2 and A are as defined in claim 1 .

13. A compound according to claim 1 , of general formula Ib

wherein R 1 , R 2 and A are as defined in claim 1 .

14. A compound according to claim 1 , wherein R 2 is optionally substituted C 1-6 alkyl or optionally substituted C 3-6 cycloalkyl.

15. A compound according to claim 14 , wherein R 2 is optionally substituted cyclopropyl.

16. A compound according to claim 1 , wherein R 3 is halogen, alkyl, cycloalkyl, heterocycloalkyl, or oxo.

17. A compound according to claim 16 , wherein R 3 is alkyl or heterocycloalkyl.

18. A compound according to claim 1 , wherein R 4 is halogen, hydroxy, or cyano, or R 4 is NR 5 R 6 , —C(O)NR 7 R 8 , —COOR 7 , —NR 5 C(O)NR 7 R 8 , —OC(O)NR 7 R 8 , —OC(O)R 3 , —NC(O)R 7 , —OR 7 , —NC(O)OR 3 , —NSO 2 R 7 , —SO 2 NR 7 R 8 , —SO 2 R 7 R 8 , alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, or heterocycloalkylalkyl, each of which is optionally substituted with one or more substituents selected from R 9 .

19. A compound according to claim 1 , wherein R 4 is hydroxy or cyano, or R 4 is —C(O)NR 7 R 8 , —COOR 7 , —NR 5 C(O)NR 7 R 8 , —OC(O)NR 7 R 8 , —NC(O)R 7 , —OR 7 , —NC(O)OR 3 , alkyl, which is optionally substituted with one or more substituents selected from R 9 ; wherein R 9 is hydrogen, halogen, or hydroxyl.

20. A compound according to claim 1 , wherein R 5 and R 6 each independently represents hydrogen, alkyl, alkenyl, cycloalkyl, or heterocycloalkyl, or R 5 and R 6 together with the nitrogen atom to which they are attached form a heterocycloalkyl ring, wherein said ring is optionally substituted with one or more alkyl groups.

21. A compound according to claim 1 , wherein R 7 and R 8 each independently represents hydrogen, alkyl, cycloalkyl, heterocycloalkyl, or alkenyloxyalkyl, each of which is optionally substituted with one or more substituents selected from the group consisting of hydroxy, halogen, oxo, cyano, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl, heterocycloalkyl, —S(O) 2 -alkyl, —S(O) 2 —NR 11 R 12 , —NC(O)-alkyl, —C(O)N-alkyl, —NC(O)O-alkyl, —OC(O)N-alkyl, —NR 11 SO 2 -alkyl, —S(O)-alkyl, or R 7 and R 8 together with the nitrogen atom to which they are attached form a heterocycloalkyl ring, wherein said ring is optionally substituted with one or more alkyl groups; wherein R 11 and R 12 are hydrogen or C 1-4 alkyl.

22. A compound according to claim 1 , wherein R 7 and R 8 each independently represents hydrogen, alkyl, cycloalkyl, alkenyloxyalkyl, each of which is optionally substituted with one or more substituents selected from the group consisting of hydroxy, oxo, cyano, alkyl, cycloalkyl, alkoxy, aryl, heteroaryl, —S(O) 2 -alkyl, —S(O) 2 —NR 11 R 12 , —NC(O)-alkyl, —NR 11 SO 2 -alkyl, or R 7 and R 8 together with the nitrogen atom to which they are attached form a heterocycloalkyl ring, wherein said ring is optionally substituted with one or more alkyl groups; wherein R 11 and R 12 are hydrogen or C 1-4 alkyl.

23. A compound according to claim 1 selected from the group consisting of:

2-Cyclopropyl-8-methoxy-5-(3-acetyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-8-methoxy-5-phenyl-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-8-methoxy-5-(4-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-8-methoxy-5-(4-trifluoromethyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-5-(3,4-dimethoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-8-methoxy-5-thiophen-2-yl-[1,2,4]triazolo[1,5-a]pyridine,

N-[3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-phenyl]-acetamide,

2-Cyclopropyl-8-methoxy-5-(3-trifluoromethoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-8-methoxy-5-(3-methoxy-phenyl)-[1,2,4]triazolo[1,5-a]pyridine,

1-[5-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-thiophen-2-yl]-ethanone,

2-Cyclopropyl-8-methoxy-5-pyrimidin-5-yl-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-5-(3-methanesulfonyl-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine,

N-[3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-phenyl]-methanesulfonamide,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-N-methyl-benzamide,

2-Cyclopropyl-8-methoxy-5-(4-acetyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridine,

N-[4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-phenyl]-acetamide,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzoic acid methyl ester,

2-Cyclopropyl-8-methoxy-5-pyridin-3-yl-[1,2,4]triazolo[1,5-a]pyridine,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzoic acid methyl ester,

2-Cyclopropyl-5-(4-methanesulfonyl-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-5-(2-fluoro-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-8-methoxy-5-[4-(2-methoxy-ethoxy)-phenyl]-[1,2,4]triazolo[1,5-a]pyridine,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzamide

5-(3-Butoxy-phenyl)-2-cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-5-(3-fluoro-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-8-methoxy-5-pyridin-4-yl-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-5-(2,4-dichloro-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine,

2-Cyclopropyl-8-methoxy-5-[4-(morpholine-4-sulfonyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridine,

N-[4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzyl]-acetamide,

N-[4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzyl]-methanesulfonamide,

2-Cyclopropyl-5-(4-fluoro-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridine,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzonitrile,

3-[4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-phenyl]-propionic acid methyl ester,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-N-(2-hydroxy-ethyl)-benzenesulfonamide,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzonitrile,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzoic acid,

[3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-phenyl]-methanol,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-N,N-dimethyl-benzamide,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzamide,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-benzoic acid,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-N,N-dimethyl-benzamide,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-N-methyl-benzamide,

2-Cyclopropyl-8-methoxy-5-piperidin-1-yl-[1,2,4]triazolo[1,5-a]pyridine,

1-[3-(2-Cyclopropyl-8-hydroxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-phenyl]-ethanone,

2-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-isonicotinonitrile,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid amide,

1-[5-(5-Cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

3-[2-(1-Hydroxymethyl-cyclopropyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-benzonitrile,

Pyrrolidine-1-carboxylic acid 1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Isopropyl-carbamic acid 1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

3-[2-(1-Benzyloxymethyl-cyclopropyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-benzonitrile,

N-{1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl}-isobutyramide,

{1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl}-carbamic acid cyclopentyl ester,

Pyrrolidine-1-carboxylic acid {1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl}-amide,

5-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-nicotinonitrile,

5-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-indan-1-one,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-2-methyl-benzonitrile,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-indan-1-one,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-5-fluoro-benzonitrile,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-2-fluoro-benzonitrile,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-2-methoxy-benzonitrile,

5-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-3H-isobenzofuran-1-one,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-5-hydroxymethyl-benzonitrile,

3-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-5-methoxy-benzonitrile,

4-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-3H-isobenzofuran-1-one,

5-(2-Cyclopropyl-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl)-2,3-dihydro-isoindol-1-one,

1-[8-Methoxy-5-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid benzylamide,

1[5-(5-Cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid benzylamide,

1-[5-(4-Cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid cyclohexylmethyl-amide,

1-[5-(4-Cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[8-Methoxy-5-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid cyclohexylmethyl-amide,

1-[5-(4-Cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1[5-(4-Cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid benzylamide,

1-[8-Methoxy-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid benzylamide,

1-[8-Methoxy-5-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[8-Methoxy-5-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[8-Methoxy-5-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid benzylamide,

1-[8-Methoxy-5-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[8-Methoxy-5-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[5-(5-Cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid cyclohexylmethyl-amide,

1-[5-(5-Cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[8-Methoxy-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-dimethylsulfamoyl-ethyl)-amide,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester,

1-[5-(3-Acetyl-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethyl ester,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid,

1-[5-(3-Acetyl-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (pyridin-3-ylmethyl)-amide,

3-{8-Methoxy-2-[1-(morpholine-4-carbonyl)-cyclopropyl]-[1,2,4]triazolo-[1,5-a]pyridin-5-yl}-benzonitrile,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid benzylamide,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-sulfamoyl-ethyl)-amide,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

3-{8-Methoxy-2-[1-(pyrrolidine-1-carbonyl)-cyclopropyl]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-benzonitrile,

2-Methyl-acrylic acid 2-({1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarbonyl}-amino)-ethyl ester,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methoxy-ethyl)-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (pyridin-3-ylmethyl)-amide,

4-{8-Methoxy-2-[1-(4-methyl-piperazine-1-carbonyl)-cyclopropyl]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-benzonitrile,

4-{8-Methoxy-2-[1-(morpholine-4-carbonyl)-cyclopropyl]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-benzonitrile,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid benzylamide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-sulfamoyl-ethyl)-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid methylamide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid ethylamide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid propylamide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid cyclopropylamide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isobutyl-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid cyanomethyl-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-acetylamino-ethyl)-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonylamino-ethyl)-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (3-morpholin-4-yl-3-oxo-propyl)-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-dimethylsulfamoyl-ethyl)-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid[2-(methanesulfonyl-methyl-amino)-ethyl]-amide,

1-[5-(3-Acetyl-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (pyridin-3-ylmethyl)-amide,

1-(3-{8-Methoxy-2-[1-(4-methyl-piperazine-1-carbonyl)-cyclopropyl]-[1,2,4]triazolo[1,5 -a]pyridin-5-yl}-phenyl)-ethanone,

1-(3-{8-Methoxy-2-[1-(morpholine-4-carbonyl)-cyclopropyl]-[1,2,4]triazolo[1,5-a]pyridin-5-yl}-phenyl)-ethanone,

1-[5-(3-Acetyl-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid benzylamide,

1-[5-(3-Acetyl-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-sulfamoyl-ethyl)-amide,

1-[5-(3-Acetyl-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

2-Methyl-acrylic acid 2-({1-[5-(3-cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarbonyl}-amino)-ethyl ester,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-hydroxy-ethyl)-amide,

Cyclohexyl-carbamic acid 1-[5-(5-cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Propyl-carbamic acid 1-[8-methoxy-5-(1-oxo-indan-5-yl)-[1,2,4]triazolo [1,5-a]pyridin-2-yl]-cyclopropylmetyl ester,

Dimethyl-carbamic acid 1-[5-(4-cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Isopropyl-carbamic acid 1-[5-(5-cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Propyl-carbamic acid 1-[8-methoxy-5-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Pyrrolidine-1-carboxylic acid 1-[5-(4-cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Isopropyl-carbamic acid 1-[5-(4-cyano-3-methoxy-phenyl)-8-methoxy-1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Propyl-carbamic acid 1-[5-(5-cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Propyl-carbamic acid 1-[5-(4-cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Pyrrolidine-1-carboxylic acid 1-[8-methoxy-5-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Isopropyl-carbamic acid 1-[8-methoxy-5-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Cyclohexyl-carbamic acid 1-[8-methoxy-5-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Cyclohexyl-carbamic acid 1-[5-(4-cyano-3-methoxy-phenyl)-8-methoxy-1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Pyrrolidine-1-carboxylic acid 1-[5-(5-cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Dimethyl-carbamic acid 1-[8-methoxy-5-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Dimethyl-carbamic acid 1-[5-(5-cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Diethyl-carbamic acid 1-[5-(4-cyano-3-methoxy-phenyl)-8-methoxy-1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Diethyl-carbamic acid 1-[8-methoxy-5-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Diethyl-carbamic acid 1-[5-(5-cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

5-[2-(1-Hydroxymethyl-cyclopropyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-nicotinonitrile,

4-(2-Cyclopropyl-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-2-methoxy-benzonitrile,

4-(2-Cyclopropyl-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-2-methyl-benzonitrile,

3-(2-Cyclopropyl-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-benzonitrile,

5-(2-Cyclopropyl-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-indan-1-one,

4-(2-Cyclopropyl-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-indan-1-one,

1-[8-(4-Cyano-3-methoxy-phenyl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[5-Methoxy-8-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[5-Methoxy-8-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[5-Hydroxy-8-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[5-Methoxy-8-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[8-(5-Cyano-pyridin-3-yl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[5-Methoxy-8-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[5-Methoxy-8-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isobutyl-amide,

1-[5-Methoxy-8-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[8-(4-Cyano-3-methoxy-phenyl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[8-(4-Cyano-3-methoxy-phenyl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[5-Methoxy-8-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[5-Methoxy-8-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[8-(4-Cyano-3-methoxy-phenyl)-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isobutyl-amide,

1-[5-Hydroxy-8-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isopropylamide,

1-[8-Methoxy-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonyl-ethyl)-amide,

1-[8-Methoxy-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid cyclohexylmethyl-amide,

1-[8-Methoxy-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-dimethylsulfamoyl-ethyl)-amide,

Diethyl-carbamic acid 1-[8-methoxy-5-(1-oxo-indan-4-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Dimethyl-carbamic acid 1-[8-methoxy-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Diethyl-carbamic acid 1-[5-(5-cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Diethyl-carbamic acid 1-[5-(4-cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

Cyclohexyl-carbamic acid 1-[8-methoxy-5-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropylmethyl ester,

4-[2-(1-Hydroxymethyl-cyclopropyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-2-methoxy-benzonitrile,

4-[2-(1-Isobutoxymethyl-cyclopropyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-2-methoxy-benzonitrile,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid isobutyl-amide,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-methanesulfonylamino-ethyl)-amide,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid cyclopropylamide,

1-[5-(3-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid cyclohexylmethyl-amide,

5-[2-(1-Isobutoxymethyl-cyclopropyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-5-yl]-nicotinonitrile,

5-(2-Cyclopropyl-5-methoxy-[1,2,4]triazolo[1,5-a]pyridin-8-yl)-nicotinonitrile,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-dimethylsulfamoyl-ethyl)-amide,

1-[5-(4-Cyano-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid[2-(methanesulfonyl-methyl-amino)-ethyl]-amide,

1-[5-(4-Cyano-3-methoxy-phenyl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-dimethylsulfamoyl-ethyl)-amide,

1-[5-(5-Cyano-pyridin-3-yl)-8-methoxy-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-dimethylsulfamoyl-ethyl)-amide,

1-[8-Methoxy-5-(1-oxo-indan-5-yl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-cyclopropanecarboxylic acid (2-dimethylsulfamoyl-ethyl)-amide,

and pharmaceutically acceptable salts, hydrates, N-oxides or solvates thereof.

24. A method of treating or ameliorating psoriasis, psoriatic arthritis, dermatitis, atopic dermatitis, seborrheic dermatitis, contact dermatitis, urticaria, pruritis, and eczema which comprises administering to a person suffering from at least one of said diseases an effective amount of one or more compounds according to according to claim 1 .