Granted Patent
B2
US 8,962,842 · App. 13/821,250 · Granted Feb 24, 2015
2-pyridone antimicrobial compositions
Inventors:
Patrick Roussel (Mulhouse, FR); Jutta Heim (Ramlinsburg, CH); Peter Schneider (Bottmingen/BL, CH); Christian Bartels (Allschwil/BL, CH); Yaoquan Liu (Castro Valley, CA); Glen Dale (Basel, CH); Daniel Milligan (San Francisco, CA)
Assignee:
Evolva SA
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Abstract
Described are a series of 2-pyridone compounds as a potent and selective new class of type II topoisomerase inhibitors with broad-spectrum antimicrobial activity having the general formula (I); where R1, R2, X, and Y are defined herein Such compounds can be used in methods for treating an infection caused by a gram-positive pathogen, a gram-negative pathogen, or a drug-resistant strains thereof.
Claims (2)
1. A compound which is 8-(4-amino-2,5-difluorophenyl)-1-cyclopropyl-9-methyl-4-oxo-4H-quinolizine-3-carboxylic acid, or a pharmaceutically acceptable salt thereof.
2. The compound according to claim 1 , wherein the compound is a pharmaceutically acceptable salt, and the pharmaceutically acceptable salt is a potassium salt.
Assignments (8)
RELEASE OF SECURITY INTEREST
Recorded Apr 29, 2026
From: OHA AGENCY LLC, IN ITS CAPACITY AS ADMINISTRATIVE AGENT
To: EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.
Reel/Frame 074509/0661 →
SECURITY INTEREST
Recorded Apr 16, 2026
From: EMERGENT BIOSOLUTIONS INC.; EMERGENT BIODEFENSE OPERATIONS LANSING LLC; EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.; EMERGENT TRAVEL HEALTH INC.; EMERGENT MANUFACTURING OPERATIONS BALTIMORE LLC
To: ORBIMED ROYALTY & CREDIT OPPORTUNITIES V, LP, AS ADMINISTRATIVE AGENT
Reel/Frame 074389/0054 →
SECURITY INTEREST
Recorded Sep 30, 2024
From: EMERGENT BIODEFENSE OPERATIONS LANSING LLC; EMERGENT BIOSOLUTIONS INC.; EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.; EMERGENT MANUFACTURING OPERATIONS BALTIMORE LLC; EMERGENT TRAVEL HEALTH INC.; EMERGENT BIOSOLUTIONS CANADA INC.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION
Reel/Frame 068746/0698 →
NOTICE OF GRANT OF SECURITY INTEREST IN U.S. PATENTS
Recorded Sep 3, 2024
From: EMERGENT BIODEFENSE OPERATIONS LANSING LLC; EMERGENT BIOSOLUTIONS CANADA INC.; EMERGENT BIOSOLUTIONS INC.; EMERGENT MANUFACTURING OPERATIONS BALTIMORE LLC; EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.; EMERGENT TRAVEL HEALTH INC.
To: OHA AGENCY LLC
Reel/Frame 068828/0233 →
NOTICE OF RELEASE OF SECURITY INTEREST IN PATENTS
Recorded Sep 3, 2024
From: WELLS FARGO BANK, NATIONAL ASSOCIATION
To: EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.
Reel/Frame 068829/0873 →
SECURITY INTEREST
Recorded May 18, 2023
From: EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 063690/0069 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jul 29, 2015
From: EVOLVA SA
To: EMERGENT PRODUCT DEVELOPMENT GAITHERSBURG INC.
Reel/Frame 036213/0139 →
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded May 28, 2013
From: ROUSSEL, PATRICK; HEIM, JUTTA; SCHNEIDER, PETER; BARTELS, CHRISTIAN; LIU, YAOQUAN; DALE, GLENN; MILLIGAN, DANIEL
To: EVOLVA SA
Reel/Frame 030494/0894 →
Continuity (2)
Provisional Application
61386721
· Sep 27, 2010