Pharmaceutical compositions for treatment of Parkinsons disease
Pharmaceutical compositions are provided for treatment of Parkinson's disease comprising a pharmaceutically acceptable carrier and a fixed dose combination of two active agents selected from compounds having either neuroprotective or symptomatic effects, or both, in Parkinson's disease patients, wherein the molar ratio of the two compounds is in the range of 1:1 to 1:100. The compositions are formulated for immediate release, controlled release, or both immediate and controlled release.
1. A method for treatment of Parkinson's disease, comprising administering to a patient in need thereof a daily dose of a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a fixed dose combination of controlled release pramipexole and controlled release rasagiline, wherein said fixed dose combination contains from about 0.01 mg to about 1.5 mg of pramipexole and from about 0.01 mg to about 1 mg of rasagiline.
2. The method according to claim 1 , wherein said fixed dose combination is in the form of a tablet, a capsule, a sachet, an orally disintegrating film, wafers, or a long lasting injectable system.
3. The method according to claim 1 , wherein said fixed dose combination contains 0.01 to 1.4 mg pramipexole.
4. The method according to claim 1 , wherein said fixed dose combination contains 0.01 to 0.9 mg rasagiline.
5. The method according to claim 4 , wherein said fixed dose combination contains 0.01 to 1.4 mg pramipexole.