Preparation and pharmaceuticals of biphenyl benzamide-derived derivatives
The present invention provides a biphenyl benzamide-derived derivatives, which structure is selected from formula I or formula II: and the synthesis and the application thereof.
1. A biphenyl benzamide-derived derivatives, which structure is selected from formula II:
wherein said R 1 , R 2 , R 3 and R 4 of the formula II is selected from the group consisting of H, halogen, CF 3 , CN, CH and OCH 3 .
2. A pharmaceutical composition of biphenyl benzamide-derived derivatives, which comprises:
(a) a structure is selected from formula II:
(b) a pharmaceutical acceptable salt and carrier of the biphenyl benzamide-derived derivatives,
wherein said R 1 , R 2 , R 3 and R 4 of the formula II is selected from the group consisting of H, halogen, CF 3 , CN, CH and OCH 3 .
3. The pharmaceutical composition of claim 2 , wherein the pharmaceutical acceptable carrier is excipient, diluents, thickeners, filler, binder, disintegrants, lubricant, oil or non-oil base, surfactant, suspending agent, gelling agent, adjuvant, anti-corrosive agent, anti-oxidant, stabilizer, coloring agent or flavor.
4. The pharmaceutical composition of claim 2 , wherein the salt is physiological acceptable salt of inorganic acid, inorganic base, organic acid or organic base.
5. The pharmaceutical composition of claim 2 , wherein said composition is powder, granule, liquid, gel or cream.
6. The pharmaceutical composition of claim 2 , wherein said composition is administrated through oral, transdermal, injection, or inhalational manner.
7. A method for synthesis of benzamide-derived derivatives, wherein a compound of formula II is synthesized by compound of formula I:
8. The method of claim 7 , wherein the compound of formula II is synthesized by compound of formula I, tetrahydrofuran/pyridine and methyl chloroformate.