IP Library Granted Patent US 8,978,491
Granted Patent B2
US 8,978,491 · App. 13/776,537 · Granted Mar 17, 2015

Systems and methods for inline sampling

Inventors: James E. Sinclair (Carlsbad, CA); B. Albert Griffin (San Diego, CA); Minh Vuong (San Diego, CA)
Assignee: Vertex Pharmaceuticals, Inc.
G01N9/02G01N1/20
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Quick Facts
Patent No.
US 8,978,491
App. No.
13/776,537
Granted
Mar 17, 2015
Kind
B2
Abstract

Methods and devices for inline sampling of a bulk material, such as a powder, are provided. The material's bulk density can be determined from samples drawn using methods and devices described herein. One embodiment of a method of sampling a material allows the material to flow through a sampling compartment, closes off the flow of material below the sampling compartment, builds up a column of material through the sampling compartment, shifts the sampling compartment to remove a slice of material in the column, and places the slice of material into a sample container. A device for sampling a material is provided in another embodiment. The device includes an inlet, an outlet aligned with the inlet, and a sample collector. The sample collector can include at least one through hole and be configured to move such that the at least one through hole can be moved into and out of alignment with the inlet and the outlet.

Claims (19)

1. A method of sampling a material, the method comprising:

providing a sample collecting element comprising a first sampling compartment and a second sampling compartment;

placing the first sampling compartment in a passage comprising an inlet and an outlet, the first sampling compartment being placed between the inlet and the outlet of the passage;

flowing the material through an entire length of the first sampling compartment, and through the passage from the inlet to the outlet;

sampling substantially the entire cross-sectional flow of the material through the passage by closing a valve in the passage below the first sampling compartment thereby building up a column of material through the first sampling compartment thereby collecting a sample of the material in the first sampling compartment;

shifting the sample collecting element thereby removing the first sampling compartment from the passage;

placing the second sampling compartment in the passage; and

weighing the sample of the material.

2. The method of claim 1 , wherein the sample collecting element comprises a disc, and removing the first sampling compartment from the passage comprises shifting the disc through the passage.

3. The method of claim 2 , wherein shifting the disc comprises rotating the disc 180° through the passage.

4. The method of claim 1 , wherein removing the first sampling compartment from the passage comprises shifting the first sampling compartment out of the passage.

5. The method of claim 1 wherein the inlet of the passage comprises a source and wherein the outlet of the passage comprises a bulk collection container along a flowpath, wherein the first sampling compartment is disposed in the flowpath between the source and the bulk collection container.

6. The method of claim 5 , further comprising reopening the flow of material from the source to the bulk collection container through the second sampling compartment.

7. The method of claim 4 , wherein shifting the sample collecting element positions the first sampling compartment and the sample of the material in a removal position wherein the sampled material flows from the first sampling compartment into a sample container.

8. The method of claim 1 , wherein shifting the sample collecting element reopens the flow of material in the passage through the second sampling compartment.

9. The method of claim 1 , further comprising:

sampling substantially the entire cross-sectional flow of the material through the passage by collecting material in the second sampling compartment;

shifting a sample collecting element thereby removing sampled material from the passage.

10. The method of claim 1 , wherein shifting the sample collecting element removes the first sampling compartment out of the passage and places the second sampling compartment in the passage.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Oct 14, 2016
From: MACQUARIE US TRADING LLC
To: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
Reel/Frame 040357/0001 →
SECURITY INTEREST Recorded Jul 10, 2014
From: VERTEX PHARMACEUTICALS INCORPORATED; VERTEX PHARMACEUTICALS (SAN DIEGO) LLC
To: MACQUARIE US TRADING LLC
Reel/Frame 033292/0311 →
CORRECTIVE ASSIGNMENT TO CORRECT THE CONVEYING PARTY PREVIOUSLY RECORDED AT REEL: 032948 FRAME: 0646. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jun 2, 2014
From: SINCLAIR, JAMES E.; VUONG, MINH; GRIFFIN, B. ALBERT
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 033082/0484 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 22, 2014
From: SINCLAIR, JAMES E.; VUONG, MINH; GRIFFIN, B. ALB ERT
To: VERTEX PHARMACEUTICALS INCORPORATED
Reel/Frame 032948/0646 →
Continuity (2)
Division 12709414 · Feb 19, 2010
Related Publication 20130160572A1 · Jun 27, 2013