Compositions and method for treatment of ischemic neuronal reperfusion injury
A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.
1. A method of treatment of neuronal reperfusion injury with ischemic neuropathy, the method comprising:
administering an effective amount of at least one of a compound having the formulas I, II or III
2. The method of claim 1 wherein the at least one compound is administered in combination with at least one of Vitamin D, Vitamin E and pluronic acid.
3. The method of claim 1 wherein the at least one compound is in the form of a suspension or emulsion.
4. The method of claim 1 wherein the at least one compound is delivered to a patient via an administration selected from the group consisting of orally, subcutaneously, parenterally, intravenously, intranasally, intrathecally, sublingually, rectally, and topically.
5. The method of claim 1 wherein the at least one compound is administered in a dosage of about 100 ng/kg per day to about 100 mg/kg per day.
6. A compound having the general formulas I, II or III
7. The compound of claim 6 further comprising at least one of Vitamin D, Vitamin E and pluronic acid.
8. The compound of claim 6 wherein the compound is in the form of a suspension or emulsion.
9. The compound of claim 6 wherein the compound has a particle size of about 1 to about 3 microns.
10. A method of making a compound having the formula
wherein the method comprises
where THP is
and THPO CH 2 is a residue of
11. The method of claim 10 further comprising the step of combining
with at least one of Vitamin D, Vitamin E and pluronic acid.