Patent
This document provides methods and materials related to Prevotella histicola preparations. For example, Prevotella histicola preparations in the form of an oral medicament or dietary supplement (e.g., a pill, tablet, capsule) are provided. In addition, methods and materials for using a Prevotella histicola preparation provided herein as an anti-inflammatory agent are provided.
1. A composition comprising live Prevotella histicola , dead Prevotella histicola , or a culture supernatant of a Prevotella histicola culture, wherein said composition is in the form of a pill, a tablet, or a capsule.
2. The composition of claim 1 , wherein said composition comprises said live Prevotella histicola.
3. The composition of claim 2 , wherein said composition contains between 1×10 7 to 1×10 11 cells of said live Prevotella histicola.
4. The composition of claim 1 , wherein said composition comprises said dead Prevotella histicola.
5. The composition of claim 4 , wherein said composition contains between 1×10 7 to 1×10 11 cells of said dead Prevotella histicola.
6. The composition of claim 1 , wherein said composition comprises said culture supernatant of said Prevotella histicola culture.
7. The composition of claim 6 , wherein said culture supernatant was obtained from said Prevotella histicola culture having greater than 1×10 7 cells of said Prevotella histicola per mL.
8. The composition of claim 1 , wherein said composition is a pill.
9. The composition of claim 1 , wherein said composition is a tablet.
10. The composition of claim 1 , wherein said composition a capsule.
11. The composition of claim 1 , wherein said live Prevotella histicola are live cells of biological deposit the Prevotella histicola deposited as NRRL accession number B-50329, wherein said dead Prevotella histicola are dead Prevotella histicola deposited as NRRL accession number B-50329, and wherein said culture supernatant is a culture supernatant of a culture of the Prevotella histicola deposited as NRRL accession number B-50329.
12. The composition of claim 1 , wherein said live Prevotella histicola , said dead Prevotella histicola , or said culture supernatant is encapsulated in said pill, said tablet, or said capsule to be released in the intestine of a mammal following oral administration of said pill, said tablet, or said capsule to said mammal.
13. The composition of claim 1 , wherein said composition further comprises a buffer.
14. The composition of claim 1 , wherein said composition further comprises a radical scavenger.
15. The composition of claim 1 , wherein said composition further comprises an antioxidant.
16. The composition of claim 1 , wherein said composition further comprises a reducing agent.
17. The composition of claim 1 , wherein said composition further comprises a botanical, vitamin, mineral, or a combination thereof.
18. The composition of claim 1 , wherein the pH of said composition is between about 6.5 and about 8.0.