IP Library Granted Patent US 9,012,392
Granted Patent B2
US 9,012,392 · App. 13/533,257 · Granted Apr 21, 2015

Treating liver diseases

Inventors: Nicholas F. LaRusso (Rochester, MN); Tetyana V. Masyuk (Rochester, MN); Melissa Muff-Luett (Minneapolis, MN)
Assignee: Mayo Foundation for Medical Education and Research
A61K38/31
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Quick Facts
Patent No.
US 9,012,392
App. No.
13/533,257
Granted
Apr 21, 2015
Kind
B2
Abstract

This document provides methods and materials related to treating liver conditions. For example, the methods and materials relating to the use of cAMP inhibitors to treat liver conditions are provided.

Claims (8)

1. A method for reducing liver weight or volume in a mammal having polycystic liver disease, said method comprising:

(a) identifying a mammal having polycystic liver disease, and

(b) contacting liver tissue of said mammal with a formulation comprising a somatostatin analog as the sole active ingredient, wherein said liver tissue comprises liver cysts, wherein the weight or volume of a liver of said mammal is reduced as compared to the weight or volume of said liver prior to said contacting step.

2. The method of claim 1 , wherein said liver tissue is human liver tissue.

3. The method of claim 1 , wherein said method comprises orally administering said somatostatin analog to said mammal.

4. The method of claim 1 , wherein said method comprises injecting said somatostatin analog into said mammal.

5. The method of claim 1 , wherein said somatostatin analog is octreotide, lanreotid or vapreotide.

6. The method of claim 1 , wherein said method comprises detecting a reduced weight or volume of said liver following said contacting step.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 23, 2013
From: LARUSSO, NICHOLAS F.; MASYUK, TETYANA V.; MUFF-LUETT, MELISSA
To: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
Reel/Frame 030262/0148 →
CONFIRMATORY LICENSE Recorded Jul 6, 2012
From: MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 028503/0412 →
Continuity (3)
Continuation 11915107
Provisional Application 60683617 · May 23, 2005
Related Publication 20120277153A1 · Nov 1, 2012