Topical palmitoyl glutathione formulations
A topical composition for application to aging skin, including an effective amount of S-acyl glutathione derivative of formula (I) wherein R 1 consists of an unsaturated or saturated C 16 acyl group and R 2 is a hydrogen, aliphatic or aromatic acyl group; and a dermatologically acceptable carrier. Preferred compositions include about 1.0% to about 3.0% by weight of S-palmitoyl glutathione.
1. A topical composition for application to aging skin, comprising:
an effective amount of S-palmitoyl glutathione of formula
a mixture of magnesium aspartate, zinc gluconate and copper gluconate; and
a dermatologically acceptable water-based carrier.
2. The topical composition of claim 1 , wherein the S-palmitoyl glutathione is present from about 0.01% to about 20% by weight.
3. The topical composition of claim 2 , wherein the S-palmitoyl glutathione is present from about 0.1% to about 5% by weight.
4. The topical composition of claim 3 , wherein the S-palmitoyl glutathione is present from about 1.0% to about 3.0% by weight.
5. The topical composition of claim 1 , wherein the composition comprises an oil in water emulsion.
6. A topical composition for application to aging skin comprising:
about 0.01% to about 20% by weight of S-palmitoyl glutathione;
a mixture of magnesium aspartate, zinc gluconate and copper gluconate;
a dermatologically acceptable water-based carrier having about 0.01% to about 15% by weight of at least one emulsifier, and water.
7. The topical composition of claim 6 , wherein the S-palmitoyl glutathione is present from about 0.1% to about 5% by weight.
8. The topical composition of claim 7 , wherein the S-palmitoyl glutathione is present from about 1.0% to about 3.0% by weight.
9. A topical composition for application to aging skin, comprising:
an effective amount of S-acyl glutathione derivative of formula (I)
wherein R 1 consists of a saturated C 16 acyl group and R 2 is a hydrogen;
a mixture of magnesium aspartate, zinc gluconate and copper gluconate; and
a dermatologically acceptable water-based carrier.
10. The composition of claim 9 , wherein the S-acyl glutathione derivative is present from about 0.01% to about 20% by weight.
11. The composition of claim 10 , wherein the S-acyl glutathione derivative is present from about 0.1% to about 5% by weight.
12. The composition of claim 11 , wherein the S-acyl glutathione derivative is present from about 1.0% to about 3.0% by weight.
13. The composition of claim 9 , wherein the composition comprises an oil in water emulsion.
14. The composition of claim 1 , wherein the composition comprises a cream.
15. The composition of claim 6 , wherein the composition comprises a cream.
16. The composition of claim 9 , wherein the composition comprises a cream.