IP Library Granted Patent US 9,028,877
Granted Patent B2
US 9,028,877 · App. 14/490,176 · Granted May 12, 2015

Bioeffective krill oil compositions

Inventors: Inge Bruheim (Volda, NO); Snorre Tilseth (Bergen, NO); Daniele Mancinelli (Orsta, NO)
Assignee: Aker Biomarine Antarctic AS
A61K35/612A61K9/4858A61K31/122A61K31/23A61K31/683A61K31/685A61K45/06C11B3/006A61K31/202
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Quick Facts
Patent No.
US 9,028,877
App. No.
14/490,176
Granted
May 12, 2015
Kind
B2
Abstract

This invention discloses new krill oil compositions characterized by having high amounts of phospholipids, astaxanthin esters and/or omega-3 contents. The krill oils are obtained from krill meal using supercritical fluid extraction in a two stage process. Stage 1 removes the neutral lipid by extracting with neat supercritical CO 2 or CO 2 plus approximately 5% of a co-solvent. Stage 2 extracts the actual krill oils by using supercritical CO 2 in combination with approximately 20% ethanol. The krill oil materials obtained are compared with commercially available krill oil and found to be more bioeffective in a number of areas such as anti-inflammation, anti-oxidant effects, improving insulin resistances and improving blood lipid profile.

Claims (24)

1. A method of production of krill oil comprising:

a) providing krill;

b) treating said krill to denature lipases and phospholipases in said krill to provide a denatured krill product; and

c) extracting oil from said denatured krill product with a polar solvent to provide a krill oil with from about 3% to about 10% w/w ether phospholipids; from about 27% to 50% w/w non-ether phospholipids so that the amount of total phospholipids in said krill oil is from about 30% to 60% w/w; and from about 20% to 50% w/w triglycerides, wherein said steps a and b are performed on a ship.

2. The method of claim 1 , wherein said treating comprises heating.

3. The method of claim 1 , wherein said krill is freshly harvested.

4. The method of claim 1 , wherein said krill oil further comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said krill oil.

5. The method of claim 4 , wherein from about 70% to 95% of said omega-3 fatty acids are attached to said total phospholipids.

6. The method of claim 1 , wherein said extracting comprises supercritical fluid extraction with a polar entrainer.

7. The method of claim 1 , further comprising encapsulating said krill oil.

8. The method of claim 1 , wherein said krill is Antarctic krill.

9. The method of claim 8 , wherein said Antarctic krill is Euphausia superba.

10. The method of claim 1 , wherein said krill is Euphausia pacifica.

11. A method of production of krill oil comprising:

a) obtaining a denatured krill product produced by treating freshly harvested krill to denature lipases and phospholipases in said krill; and

b) extracting oil from said denatured krill product with a polar solvent to provide a krill oil with from about 3% to about 10% w/w ether phospholipids; from about 27% to 50% w/w non-ether phospholipids so that the amount of total phospholipids in the krill oil is from about 30% to 60% w/w; and from about 20% to 50% w/w triglycerides.

12. The method of claim 11 , wherein said treating comprises heating.

13. The method of claim 11 , wherein said krill oil further comprises from about 20% to 35% omega-3 fatty acids as a percentage of total fatty acids in said krill oil.

14. The method of claim 13 , wherein from about 70% to 95% of said omega-3fatty acids are attached to said total phospholipids.

15. The method of claim 11 , wherein said extracting comprises supercritical fluid extraction with a polar entrainer.

16. The method of claim 11 , further comprising encapsulating said krill oil.

17. The method of claim 11 , wherein said krill is Antarctic krill.

18. The method of claim 17 , wherein said Antarctic krill is Euphausia superba.

19. The method of claim 11 , wherein said krill is Euphausia pacifica.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 16, 2015
From: AKER BIOMARINE AS
To: AKER BIOMARINE ANTARCTIC AS
Reel/Frame 034734/0841 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2014
From: BRUHEIM, INGE; TILSETH, SNORRE; MANCINELLI, DANIELE
To: AKER BIOMARINE AS
Reel/Frame 034114/0930 →
Continuity (6)
Continuation 12057775 · Mar 28, 2008
Provisional Application 60920483 · Mar 28, 2007
Provisional Application 60975058 · Sep 25, 2007
Provisional Application 60983446 · Oct 29, 2007
Provisional Application 61024072 · Jan 28, 2008
Related Publication 20150004223A1 · Jan 1, 2015