Valve for lab-on-a-chip systems, method for actuating and for producing valve
A substrate of a lab-on-a-chip system has two adjacent recesses, one serving as a flow channel and the other one being filled with an elastomer compound. In a first state, the elastomer compound and the substrate delimit the flow channel in a section. In a second state, the elastomer compound takes up the space in the recess in the substrate along a cross-section of the flow channel, thereby completely closing the flow channel. The substrate and the elastomer compound may be produced by injection molding techniques.
1. A valve for opening and closing a flow channel in a lab-on-a-chip system, comprising:
a support body having at least one first recess forming a flow channel and a second recess directly next to a subregion of the at least one first recess;
an elastomer compound at least partially filling the second recess, the elastomer compound and the support body together forming boundary surfaces of the flow channel in the subregion of the at least one first recess in a first state, and the elastomer compound being deformed in a second state under pressure causing a cross section of the flow channel in the at least one first recess to be fully filled, so that the flow channel is closed; and
a self-adhesive film covering the at least one first recess and the second recess in a liquid-tight and/or gas-tight fashion.
2. The valve as claimed in claim 1 , wherein the support body consists of at least one of polycarbonate and polypropylene.
3. The valve as claimed in claim 1 , wherein the elastomer compound is a thermoplastic elastomer formed of one of rubber and a mixture of polypropylene and ethylene propylene diene M-class elastomer.
4. The valve as claimed in claim 1 , wherein the support body is configured as a flat chip card.
5. The valve as claimed in claim 4 , wherein the at least one first recess and the second recess are formed in and open toward a front side of the flat chip card.
6. The valve as claimed in claim 5 , wherein the at least one first recess and/or the second recess have a cross-sectional diameter of less than 10 millimeters.
7. The valve as claimed in claim 5 , wherein the at least one first recess has an aspect ratio of the cross-sectional height to width of more than 1 so as to facilitate closure of the valve in response to pressure on the elastomer compound.
8. The valve as claimed in claim 5 , wherein the flow channel has an indentation in the subregion of the at least one first recess.
9. The valve as claimed in claim 6 , wherein the at least one first recess and/or the second recess have a cross-sectional diameter of less than 20 micrometers.
10. The valve as claimed in claim 8 , wherein the second recess is a cylinder with rim, a rim elevation being formed on an outer circumference of the rim.
11. A method for actuating a valve, for opening and closing a flow channel in a lab-on-a-chip system, formed by a support body having at least one first recess forming a flow channel and a second recess directly next to a subregion of the at least one first recess and an elastomer compound at least partially filling the second recess, comprising:
exerting a pressure force on the elastomer compound to deform the elastomer compound and fill the at least one first recess by deformation along a cross section of the flow channel so that the flow channel is closed in a liquid-tight and/or gas-tight fashion; and
releasing the pressure force to cause the elastomer compound to substantially return to an original shape, thereby opening the flow channel,
wherein said exerting of the pressure force is by movement of a plunger, and
wherein the pressure force is transmitted indirectly onto the elastomer compound by a film.
12. The method as claimed in claim 11 , wherein the support body is fastened by flat clamping on two opposite sides, and
wherein the pressure force is exerted on the elastomer compound from a first side opposite the at least one first recess and the second recess.
13. The method as claimed in claim 12 , wherein the pressure force is exerted on the elastomer compound in a first direction, substantially perpendicular to a rear side of the support body, and the elastomer compound is deformed substantially along a second direction along the cross section of the flow channel, the second direction being substantially perpendicular to the first direction and substantially parallel to the rear side of the support body.
14. A method for producing a valve for opening and closing a flow channel in a lab-on-a-chip system by exerting pressure causing deformation of an elastomer compound along a cross section of the flow channel thereby closing the flow channel in a liquid-tight and/or gas-tight fashion, and releasing the pressure to cause the elastomer compound to substantially return to an original shape, thereby opening the flow channel, comprising:
using injection molding technology to produce a support body with at least one first recess forming the flow channel and a second recess directly next to a subregion of the at least one first recess, and
applying a self-adhesive film covering the at least one first recess and the second recess in a liquid-tight fashion.
15. The method as claimed in claim 14 , further comprising introducing the elastomer compound into the second recess by injection molding technology.