Vasoprotective and cardioprotective antidiabetic therapy
The present invention relates to certain DPP-4 inhibitors for treating and/or preventing oxidative stress, vascular stress and/or endothelial dysfunction as well as to the use of such DPP-4 inhibitors in treatment and/or prevention of diabetic or non-diabetic patients, including patient groups at risk of cardiovascular and/or renal disease.
1. A method for treating oxidative stress, vascular stress and/or endothelial dysfunction in a sepsis patient in need thereof, the method comprising administering linagliptin to the patient.
2. The method of claim 1 , wherein the sepsis patient is a diabetic patient or a nondiabetic patient.
3. A method for treating sepsis comprising administering linagliptin to a patient in need thereof.
4. The method of claim 3 , wherein the linagliptin is administered orally to the patient.
5. The method of claim 3 , wherein the linagliptin is administered intravenously to the patient.