IP Library Granted Patent US 9,039,621
Granted Patent B2
US 9,039,621 · App. 13/560,236 · Granted May 26, 2015

Non-invasive ultrasonic gingival tissue diagnosis

Inventors: Osama M. Mukdadi (Morgantown, WV); Ahmed M. Mahmoud (Pittsburgh, PA); Eros S. Chaves (Morgantown, WV); Richard Crout (Morgantown, WV)
Assignee: THE UNITED STATES OF AMERICA NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), NIH DIVISION OF EXTRAMURAL INVENTIONS AND TECHNOLOGY RESOURCES (DEITR)
A61B8/08A61B8/12G06T7/0012G06F19/321A61B8/5207
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Quick Facts
Patent No.
US 9,039,621
App. No.
13/560,236
Granted
May 26, 2015
Kind
B2
Abstract

Disclosed are various embodiments for echoperiodontal imaging. In one embodiment, a system includes a transducer configured to transmit a series of ultrasonic signals at a plurality of corresponding locations along soft tissue of a jaw and receive a plurality of echo signals; and an imaging system controller configured to obtain a plurality of echo signal data of the soft tissue and a plurality of transducer positions, where each echo signal data corresponds to one of the plurality of transducer position.

Claims (42)

1. A system for echoperiodontal imaging of gingival tissue, comprising:

a transducer adapted to:

be positioned along a plurality of locations of gingival tissue for a region of interest of a jaw;

transmit a series of ultrasonic signals at the plurality of locations of the gingival tissue for the region of interest of the jaw, and

receive a plurality of echo signals, each echo signal corresponding to one of the transmitted ultrasonic signals at one of the plurality of locations of the gingival tissue; and

imaging system computer hardware configured to:

coordinate transmission of the series of ultrasonic signals and reception of the corresponding echo signals,

obtain a plurality of echo signal data of the gingival tissue and a plurality of transducer positions, where each echo signal data corresponds to one of the plurality of transducer positions and is derived from the received plurality of echo signals;

dividing a region of interest in the echo signals of the plurality of corresponding locations into a plurality of two-dimensional kernels comprising sub-regions of the region of interest;

convert each of the plurality of two-dimensional kernels into a plurality of one-dimensional signal vectors from neighborhood pixels within a two-dimensional kernel and the one-dimensional signal vectors are used to extract parametric values in a time-domain, a frequency-domain, and a wavelet-domain; and

reconstruct at least a two-dimensional image of a portion of the gingival tissue of the jaw based upon the obtained echo signal data, the plurality of transducer positions, and the parametric values from at least the time-domain, the frequency-domain, and the wavelet-domain, wherein the at least a two-dimensional image comprises a parametric ultrasound image with pixel values represented using the parametric values from the time-domain, the frequency-domain, and the wavelet-domain.

2. The system of claim 1 , wherein the imaging system computer hardware provides access to B-mode images.

3. The system of claim 1 , wherein the kernels overlap in space by approximately 90%.

4. The system of claim 1 , wherein the imaging system computer hardware is further configured to construct parametric ultrasound images by calculating and assigning a value of each parameter in any of the time, frequency, and wavelet domains to a pixel representing a center of the two-dimensional kernel.

5. The system of claim 1 , wherein the transducer comprises an extraoral probe that is positioned outside a mouth of a human subject.

6. The system of claim 1 , wherein the transducer comprises a linear array side intraoral probe that is positioned inside a mouth of a human subject.

7. The system of claim 1 , wherein the transducer is a transducer array.

8. The system of claim 1 , wherein the image is a three-dimensional volume rendering of the gingival tissue of the jaw.

9. A method for echoperiodontal imaging, comprising:

positioning a transducer adjacent to a jaw of a subject;

transmitting a series of ultrasonic signals at a plurality of corresponding locations along the jaw of the subject;

receiving a plurality of echo signals, each echo signal corresponding to one of the transmitted ultrasonic signals;

obtaining a plurality of echo signal data and a plurality of corresponding transducer positions, where each echo signal data corresponds to one of the plurality of transducer positions and is derived from the received plurality of echo signals;

dividing a region of interest in the echo signals of the plurality of corresponding locations into a plurality of two-dimensional kernels comprising sub-regions of the region of interest;

for each one of the plurality of two-dimensional kernels, converting a two-dimensional kernel into a plurality of one-dimensional signal vectors from neighborhood pixels within the two-dimensional kernel;

extracting parameters in a time-domain, a frequency-domain, and a wavelet-domain using the one-dimensional signal vectors; and

reconstructing at least two-dimensional image data of a portion of soft tissue adjacent to the jaw for display on a display device based upon the obtained plurality of echo signal data, the plurality of corresponding transducer positions, and parametric values from the time-domain, the frequency-domain, and the wavelet-domain, wherein the at least two-dimensional image data comprises a parametric ultrasound image with pixel values represented using the parametric values from the time-domain, the frequency-domain, and the wavelet-domain.

10. The method of claim 9 , wherein the transducer is a one-dimensional transducer array.

11. The method of claim 9 , wherein the transducer is a two-dimensional transducer array.

12. The method of claim 9 , further comprising providing the image data for display of a three-dimensional volume rendering of the portion of the soft tissue of the jaw on the display device.

13. The method of claim 9 , wherein the soft tissue comprises gingival tissue.

14. The method of claim 9 , wherein the transducer is positioned external to a mouth of the subject.

15. The method of claim 9 , wherein the transducer is positioned inside a mouth of the subject.

16. A method for echoperiodontal imaging, comprising:

transmitting a series of ultrasonic signals at a plurality of corresponding locations of gingival tissue along a region of interest of a jaw of a subject;

receiving a plurality of echo signals, each echo signal corresponding to one of the transmitted ultrasonic signals at one of the plurality of corresponding locations of gingival tissue;

dividing the region of interest in the echo signals into a plurality of two-dimensional kernels comprising sub-regions of the region of interest;

for each one of the plurality of two-dimensional kernels, converting a two-dimensional kernel into a plurality of one-dimensional signal vectors from neighborhood pixels within the two-dimensional kernel;

extracting parameters in a time-domain, frequency-domain, and wavelet-domain using the one-dimensional signal vectors; and

constructing parametric ultrasound images by calculating and assigning a value of each parameter in any of the time, frequency, and wavelet domains to a pixel representing a center of the two-dimensional kernel.

17. The method of claim 16 , wherein the ultrasonic signals are transmitted by a transducer positioned outside a mouth of the subject.

18. The method of claim 16 , wherein the ultrasonic signals are transmitted by a transducer positioned inside a mouth of the subject.

Assignments (4)
CONFIRMATORY LICENSE Recorded May 14, 2013
From: WEST VIRGINIA UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030409/0786 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2012
From: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION, WVU OFFICE OF TECHNOLOGY TRANSFER; WEST VIRGINIA UNIVERSITY RESEARCH CORP., WVU OFFICE OF TECHNOLOGY TRANSFER & WVU BUSINESS INCUBATOR; WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION
To: WEST VIRGINIA UNIVERSITY
Reel/Frame 029017/0452 →
CONFIRMATORY LICENSE Recorded Sep 25, 2012
From: WEST VIRGINIA UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 029033/0369 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 10, 2012
From: MUKDADI, OSAMA M.; MAHMOUD, AHMED M.; CHAVES, EROS S.; CROUT, RICHARD
To: WEST VIRGINIA UNIVERSITY RESEARCH CORPORATION, WVU OFFICE OF TECHNOLOGY TRANSFER
Reel/Frame 028926/0749 →
Continuity (2)
Provisional Application 61574037 · Jul 27, 2011
Related Publication 20130029293A1 · Jan 31, 2013