Continuous administration of dopa decarboxylase inhibitors and compositions for same
Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
1. A pharmaceutically acceptable liquid composition comprising levodopa, arginine, and about 0.5% to about 3% by weight carbidopa, wherein the pH of the liquid composition is 8 to 10 at 25° C.
2. The pharmaceutically acceptable liquid composition of claim 1 , wherein the pH is about 9.5 at 25° C.
3. The composition of claim 2 , comprising up to about 2% by weight carbidopa.
4. The pharmaceutically acceptable liquid composition of claim 2 , comprising about 6% by weight levodopa.
5. The pharmaceutically acceptable liquid composition of claim 4 , comprising about 1 to about 20% by weight arginine.
6. The pharmaceutically acceptable liquid composition of claim 5 , further comprising N-acetyl cysteine.
7. The pharmaceutically acceptable liquid composition of claim 5 , further comprising ascorbic acid.
8. The pharmaceutically acceptable liquid composition of claim 1 , wherein the liquid composition has no precipitation when held for 48 hours at room temperature.
9. A pharmaceutically acceptable liquid composition with a pH of 9.5 at 25° C., comprising about 6% by weight levodopa, about 1 to about 20% by weight arginine, and ascorbic acid.
10. The pharmaceutically acceptable liquid composition of claim 9 , further comprising about 0.5% to about 3% by weight carbidopa.
11. The pharmaceutically acceptable liquid composition of claim 10 comprising up to 2% by weight carbidopa.
12. A pharmaceutically acceptable liquid composition with a pH of 9.5 at 25° C., comprising about 6% by weight levodopa, about 1 to about 20% by weight arginine, about 0.5% to about 3% by weight carbidopa, and ascorbic acid.
13. The pharmaceutically acceptable liquid composition of claim 12 , further comprising N-acetyl cysteine.
14. A method of treating a disease or disorder characterized by reduced levels of dopamine in a patient's brain, comprising administering to said patient an amount of a composition of claim 1 in an amount effective to treat said disease or disorder.
15. The method of claim 14 , wherein said administering is subcutaneous, transdermal, intradermal, intravenous, oral, intraduodenal, intramuscular, and/or direct absorption through mucous membrane tissues.
16. The method of claim 14 , wherein said administration is continuous.
17. The method of claim 14 , wherein said disease or disorder is Parkinson's disease or secondary parkinsonism.
18. The method of claim 17 , wherein said disease is Parkinson's disease.
19. The method of claim 18 , wherein said administering is continuous.
20. The method of claim 19 , wherein said administering is subcutaneous.
21. An infusion pump comprising the composition of claim 1 .