IP Library Granted Patent US 9,044,443
Granted Patent B2
US 9,044,443 · App. 13/912,874 · Granted Jun 2, 2015

Methods of treating autism

Inventors: Kathryn Roberts (Cambridge, MA); Randall L. Carpenter (Cambridge, MA); Mark F. Bear (Cambridge, MA)
Assignee: CLINICAL RESEARCH ASSOCIATES, LLC
A61K31/197A61K31/195A61K31/215A61K31/428
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Quick Facts
Patent No.
US 9,044,443
App. No.
13/912,874
Granted
Jun 2, 2015
Kind
B2
Abstract

Subjects having autism are treated with a composition that includes gamma-aminobutyric acid agonists. The gamma-aminobutyric acid agonist (GABA) can be a GABA(B) agonist, such as baclofen. The humans can be administered the GABA(B) agonist in a single dose or multiple doses.

Claims (6)

1. A method of improving at least one of motivation, calmness, class participation, ability to tolerate stress and sleep patterns in a human having autism spectrum disorder, comprising the step of orally administering to the human a composition that includes a therapeutically effective amount of at least one GABA(B) agonist.

2. The method of claim 1 , wherein the GABA(B) agonist is administered to the human in a dose of about 0.001 mg/kg/day to about 5 mg/kg/day.

3. The method of claim 1 , wherein the GABA(B) agonist is administered to the human once a day.

4. The method of claim 1 , wherein the GABA(B) agonist is administered to the human twice a day.

5. The method of claim 1 , wherein the GABA(B) agonist is administered to the human in a dose of about 1 mg twice a day.

6. The method of claim 1 , wherein the GABA(B) agonist is administered to the human in a dose of about 10 mg three times a day.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 29, 2014
From: SEASIDE THERAPEUTICS, INC.
To: CLINICAL RESEARCH ASSOCIATES, LLC
Reel/Frame 032076/0588 →
Continuity (7)
Continuation 13614715 · Sep 13, 2012
Continuation 13362985 · Jan 31, 2012
Continuation 12454202 · May 14, 2009
Continuation PCTUS2007024311 · Nov 21, 2007
Provisional Application 60860733 · Nov 22, 2006
Provisional Application 61001567 · Nov 2, 2007
Related Publication 20130261186A1 · Oct 3, 2013