IP Library Granted Patent US 9,044,470
Granted Patent B2
US 9,044,470 · App. 13/870,341 · Granted Jun 2, 2015

Iminosugars and methods of treating viral diseases

Inventors: Urban Ramstedt (Silver Spring, MD); Brennan Klose (Silver Spring, MD); Nicole Zitzmann (Oxford, GB); Raymond A. Dwek (Oxford, GB); Terry D. Butters (Oxford, GB)
Assignees: United Therapeutics Corporation; The Chancellor, Masters and Scholars of The University of Oxford
A61K31/445A61K31/665
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Quick Facts
Patent No.
US 9,044,470
App. No.
13/870,341
Granted
Jun 2, 2015
Kind
B2
Abstract

Provided are methods of treating or preventing viral infections caused by or associated with a Dengue virus using iminosugars.

Claims (6)

1. A method of treating Dengue viral infection comprising administering to a subject in need thereof an effective amount of the compound, where in the compound is N-(7-oxadecyl)deoxynojirimycin or a pharmaceutically acceptable salt thereof, or N—(N-{4′-azido-2 nitrophenyl}-6-aminohexyl)deoxynojirimycin or a pharmaceutically acceptable salt thereof.

2. The method of claim 1 , wherein the compound is N-(7-oxadecyl)deoxynojirimycin or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 , wherein the compound is N—(N-{4′-azido-2′-nitrophenyl}-6-aminohexyl)deoxynojirimycin or a pharmaceutically acceptable salt thereof.

4. The method of claim 1 , wherein the viral infection is caused by or associated with a Dengue 2 virus.

5. The method of claim 1 , wherein the subject is a mammal.

6. The method of claim 1 , wherein the subject is a human being.

Assignments (2)
CHANGE OF NAME Recorded Sep 8, 2016
From: UNITHER VIROLOGY, LLC
To: EMERGENT VIROLOGY LLC
Reel/Frame 039950/0938 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 23, 2015
From: UNITED THERAPEUTICS CORPORATION
To: UNITHER VIROLOGY, LLC
Reel/Frame 036869/0480 →
Continuity (4)
Continuation 12656992 · Feb 22, 2010
Provisional Application 61202367 · Feb 23, 2009
Provisional Application 61272255 · Sep 4, 2009
Related Publication 20130237567A1 · Sep 12, 2013