IP Library › Granted Patent US 9,044,510
Granted Patent B2
US 9,044,510 · App. 12/740,819 · Granted Jun 2, 2015

Compositions and methods for treating pruritus

Inventors: Zhou-feng Chen (St. Louis, MO); Yan-gang Sun (St. Louis, MO)
Assignee: Washington University
A61K45/06A61K9/0019A61K31/00A61K31/485A61K38/168A61K47/10A61K47/44
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Quick Facts
Patent No.
US 9,044,510
App. No.
12/740,819
Granted
Jun 2, 2015
Kind
B2
Abstract

The present invention encompasses methods and compositions for alleviating pruritis. The compositions may comprise an analgesic agent.

Claims (2)

1. A method for treating pruritus in a subject in need of treatment thereof, the method comprising intrathecally administering a gastrin-releasing peptide receptor (GRPR) antagonist to the subject, such that pruritus is reduced compared to a subject that was not administered a GRPR antagonist.

2. A method for treating pruritus in a subject in need of treatment thereof, the method comprising intrathecally administering to the subject a composition comprising a neurotoxin coupled to a gastrin-releasing peptide (GRP), such that the itch sensation of the patient is reduced compared to a patient that is not administered the composition.

Assignments (2)
CONFIRMATORY LICENSE Recorded Mar 31, 2011
From: WASHINGTON UNIVERSITY
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 026066/0023 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 13, 2010
From: CHEN, ZHOUFENG; SUN, YAN GANG
To: WASHINGTON UNIVERSITY
Reel/Frame 024977/0117 →
Continuity (3)
Provisional Application 60984532 · Nov 1, 2007
Provisional Application 61023478 · Jan 25, 2008
Related Publication 20100310580A1 · Dec 9, 2010