Inhibition of quorum sensing-mediated processes in bacteria
Methods are provided for identifying molecules that can be used to positively and negatively manipulate quorum-sensing-mediated communication to control bacterial behavior. Small-molecule antagonists that disrupt quorum-sensing-mediated activities are identified. Methods are provided for disrupting detection of acyl-homoserine lactone autoinducer in Gram-negative bacteria by contacting the bacteria with the antagonists. Methods of inhibiting quorum sensing-mediated activity in Gram-negative bacteria are provided wherein the activity is pathogenicity, bioluminescence, siderophore production, type III secretion, or metalloprotease production.
1. A medical device supplemented with the compound or compounds whose structure is selected from the group consisting of:
in a concentration sufficient to disrupt detection of autoinducer-1.
2. The medical device of claim 1 that is a catheter.
3. A personal hygiene product or device within or on which is contained one or more of the compounds whose structure is selected from the group consisting of:
4. A bacterial biofilm-inhibiting composition comprising one or more compounds whose structure is selected from the group consisting of:
together with a bacteriocidal agent.
5. The medical device of claim 1 , wherein the device is coated with the compound or compounds.
6. The medical device of claim 1 , wherein the device is impregnated with the compound or compounds.
7. A personal hygiene device of claim 3 that is a toothbrush or tongue depressor.
8. A personal hygiene product of claim 3 that is soap, toothpaste, dental floss, laundry detergent or moisturizing lotion.