IP Library › Granted Patent US 9,045,736
Granted Patent B2
US 9,045,736 · App. 13/724,556 · Granted Jun 2, 2015

Methods for enriching for pancreatic endocrine cells

Inventors: Olivia Kelly (San Diego, CA); Anne Bang (San Diego, CA)
Assignee: ViaCyte, Inc.
C12N5/0676C12N5/0678G01N33/68C12N2501/50C12N2501/599C12N2506/02
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Quick Facts
Patent No.
US 9,045,736
App. No.
13/724,556
Granted
Jun 2, 2015
Kind
B2
Abstract

The present disclosure relates to compositions and methods comprising cell surface markers for hES-derived cells, in particular, endoderm lineage cells including pancreatic endoderm-type cells, derived from hES cells.

Claims (4)

1. A method of enriching for cells expressing chromogranin A comprising:

a) exposing an in vitro cell population comprising pancreatic chromogranin A positive cells to a ligand that binds CD200, CD318, CD142, CD57 or CD340; and

b) selecting cells from said in vitro cell population that express CD200, CD318 or CD57 or selecting cells from said in vitro cell population that do not express CD142 or CD340, thereby enriching for cells expressing chromogranin A.

2. The method of claim 1 , wherein the ligand is an antibody or fragment thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 28, 2013
From: KELLY, OLIVIA; BANG, ANNE
To: VIACYTE, INC.
Reel/Frame 029898/0305 →
Continuity (2)
Continuation In Part 12107020 · Apr 21, 2008
Related Publication 20130122520A1 · May 16, 2013