IP Library › Granted Patent US 9,051,373
Granted Patent B2
US 9,051,373 · App. 13/764,693 · Granted Jun 9, 2015

Optimized Fc variants

Inventors: Gregory Alan Lazar (Indianapolis, IN); Wei Dang (Pasadena, CA); John Desjarlais (Pasadena, CA); Sher Bahadur Karki (Santa Monica, CA); Omid Vafa (Monrovia, CA); Robert Hayes (Paoli, PA); Jost Vielmetter (Altadena, CA)
Assignee: Xencor, Inc.
C07K16/2896C07K16/2863C07K16/2893C07K16/283C07K16/2887C07K16/32C07K2317/14C07K2317/41C07K2317/71C07K2317/72C07K2317/732C07K2317/734C07K2317/34
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Quick Facts
Patent No.
US 9,051,373
App. No.
13/764,693
Granted
Jun 9, 2015
Kind
B2
Abstract

The present invention relates to a variant Fc region comprising an amino acid substitution at position 238 of the Fc region as compared to a human parent Fc region, wherein the variant Fc region comprises a 238D substitution, wherein the variant Fc region binds FcγRIIb with increased binding affinity compared to a human parent Fc region.

Claims (4)

1. A polypeptide comprising a variant Fc region comprising an amino acid substitution at position 238 of the Fc region as compared to a human parent Fc region, wherein the variant Fc region comprises a 238D substitution, wherein the variant Fc region binds FcγRIIb with increased binding affinity compared to a human parent Fc region, wherein the numbering is according to the EU index.

2. A polypeptide according to claim 1 wherein said polypeptide is an antibody.

3. A polypeptide according to claim 2 wherein said antibody is selected from the group consisting of a chimeric antibody, a humanized antibody, a monoclonal antibody or a human antibody.

4. A polypeptide according to claim 1 wherein said polypeptide is an immunoadhesin.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2014
From: LAZAR, GREGORY ALAN; CHIRINO, ARTHUR J.; DANG, WEI; DESJARLAIS, JOHN RUDOLPH; DOBERSTEIN, STEPHEN KOHL; HAYES, ROBERT J.; KARKI, SHER BAHADUR; VAFA, OMID
To: XENCOR, INC.
Reel/Frame 033821/0223 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 25, 2014
From: LAZAR, GREGORY ALAN; CHIRINO, ARTHUR J.; DANG, WEI; DESJARLAIS, JOHN R.; DOBERSTEIN, STEPHEN KOHL; HAYES, ROBERT J.; KARKI, SHER BAHADUR; VAFA, OMID
To: XENCOR, INC.
Reel/Frame 033821/0416 →
Continuity (11)
Continuation 12896610 · Oct 1, 2010
Continuation 11124620 · May 5, 2005
Continuation In Part 10822231 · Mar 26, 2004
Continuation In Part 10672280 · Sep 26, 2003
Provisional Application 60627774 · Nov 12, 2004
Provisional Application 60626991 · Nov 10, 2004
Provisional Application 60627026 · Nov 9, 2004
Provisional Application 60589906 · Jul 20, 2004
Provisional Application 60477839 · Jun 12, 2003
Provisional Application 60467606 · May 2, 2003
Related Publication 20130209457A1 · Aug 15, 2013