Use of tylvalosin as antiviral agent
The invention relates to the use of a macrolide antibiotic, tylvalosin, as an anti-viral agent. Tylvalosin is particularly useful for the treatment of PRRSV.
1. A method of treating a virus infection comprising administering tylvalosin or salts or esters thereof, or a pharmaceutical composition comprising tylvalosin or salts or esters thereof, to a subject having a viral infection wherein the virus is porcine reproductive and respiratory system virus (PRRSV) that uses the late endosomal or lysosomal pathway to infect cells.
2. A The method according to claim 1 , wherein the virus requires a pH within the endosome or lysosome of below 6.5.
3. A method of treating a porcine reproductive and respiratory system virus infection comprising administering tylvalosin or salts or esters thereof, or a pharmaceutical composition comprising tylvalosin or salts or esters thereof, to a subject having a porcine reproductive and respiratory system viral infection.