4-(8-methoxy-1-((1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1 H-imidazo[4,5-C]quinolin-7-yl)-3,5-dimethylisoxazole and its use as bromodomain inhibitor
Novel quinoline compounds pharmaceutical compositions containing such compounds and their use in therapy.
1. A compound of formula (I) which is 4-(8-methoxy-1-(1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole
or a salt thereof.
2. A compound of formula (IA) which is 4-(8-methoxy-1-((R)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole
or a salt thereof.
3. A compound of formula (IB) which is 4-(8-methoxy-1-((S)-1-methoxypropan-2-yl)-2-(tetrahydro-2H-pyran-4-yl)-1H-imidazo[4,5-c]quinolin-7-yl)-3,5-dimethylisoxazole
or a salt thereof.
4. A compound according to claim 2 or a pharmaceutically acceptable salt thereof.
5. A pharmaceutical composition which comprises a compound or a pharmaceutically acceptable salt thereof as defined in claim 4 and one or more pharmaceutically acceptable carriers, diluents or excipients.
6. A combination pharmaceutical product comprising a compound or a pharmaceutically acceptable salt thereof as defined in claim 4 together with one or more other therapeutically active agents.
7. A method of treating a chronic autoimmune and/or inflammatory condition which comprises administering, to a human subject in need thereof, a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof as defined in claim 4 .
8. A method of treating cancer which comprises administering, to a human subject in need thereof, a therapeutically effective amount of a compound or a pharmaceutically acceptable salt thereof as defined in claim 4 .
9. A method according to claim 8 wherein said cancer is a leukaemia, a NUT-midline carcinoma, multiple myeloma, lung cancer, a neuroblastoma, Burkitt's lymphoma, cervical cancer, esophageal cancer, ovarian cancer, breast cancer, or colorectal cancer.
10. A salt of a compound of Formula (IA) according to claim 2 wherein said salt is selected from the group consisting of hydrochloride, sulfate, maleate, fumarate, citrate, p-toluenesulfonate, benzenesulfonate, and methanesulfonate salt.
11. A salt according to claim 10 wherein said salt is a methanesulfonate salt.
12. A compound of formula (IA) which is 4 -( 8 -methoxy- 1 -((R)- 1 -methoxypropan- 2 -yl)- 2 -(tetrahydro- 2 H-pyran- 4 -yl)- 1 H- imidazo[ 4 , 5 -c]quinolin- 7 -yl)- 3 , 5 -dimethylisoxazole.