TWEAK/Fn14 system regulates skeletal muscle atrophy and regeneration
View Patent ↗The invention provides methods for preventing loss and augmenting regeneration of skeletal muscle by decreasing the activity of the TWEAK/Fn14 system.
1. A method for reducing loss of skeletal muscle in a patient having a battlefield injury, an accidental injury, cancer, anorexia or diabetes, comprising administering to a patient having a battlefield injury, an accidental injury, cancer, anorexia or diabetes a therapeutically effective amount of an agent that decreases the activity of the TWEAK/Fn14 system so as to reduce the loss of skeletal muscle, wherein the agent is a TWEAK neutralizing antibody that blocks TWEAK activity.
2. The method of claim 1 , wherein the patient has a battlefield or accidental injury.
3. The method of claim 2 , wherein the patient has a battlefield injury.
4. The method of claim 1 , wherein the patient has cancer.
5. The method of claim 1 , wherein the patient has anorexia.
6. The method of claim 1 , wherein the patient has diabetes.
7. The method of claim 6 , wherein the patient has type II diabetes.
8. The method of claim 1 , wherein the skeletal muscle is a soleus, tibial anteriors, gastrocnemius, EDL, diaphragm, biceps, triceps, quadriceps, facial, tongue, or abdominal muscle.
9. The method of claim 1 , wherein the administration of the therapeutically effective amount of an agent that decreases the activity of the TWEAK/Fn14 system also reduces the loss of force production by the skeletal muscle.
10. A method for reducing loss of force production by skeletal muscle in a patient having a battlefield injury, an accidental injury, cancer, anorexia or diabetes, comprising administering to a patient having a battlefield injury, an accidental injury, cancer, anorexia or diabetes a therapeutically effective amount of an agent that decreases the activity of the TWEAK/Fn14 system so as to reduce the loss of force production by the skeletal muscle, wherein the agent is a TWEAK neutralizing antibody that blocks TWEAK activity.
11. The method of claim 10 , wherein the patient has a battlefield or accidental injury.
12. The method of claim 11 , wherein the patient has a battlefield injury.
13. The method of claim 10 , wherein the patient has cancer.
14. The method of claim 10 , wherein the patient has anorxia.
15. The method of claim 10 , wherein the patient has diabetes.
16. The method of claim 15 , wherein the patient has type II diabetes.
17. The method of claim 10 , wherein the skeletal muscle is a soleus, tibial anteriors, gastrocnemius, EDL, diaphragm, biceps, triceps, quadriceps, facial, tongue, or abdominal muscle.